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Low noise back pressure regulator for supercritical fluid chromatography

  • US 8,419,936 B2
  • Filed: 03/23/2010
  • Issued: 04/16/2013
  • Est. Priority Date: 03/23/2010
  • Status: Active Grant
First Claim
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1. A system for chromatography, comprising:

  • a first pump for pumping a first relatively incompressible fluid flowstream;

    a second pump for pumping a second relatively compressible solvent fluid flowstream;

    mixing device that combines said first and second flowstreams;

    an injection device that can introduce samples or solutions into any of said flowstreams;

    a chromatography separation column, downstream of said mixing device and that can receive said combined flowstream;

    a detector, for detecting a concentration of a constituent in one of said flowstreams;

    a computer controller, directing certain operations of the system; and

    a back pressure regulator, located downstream of said column, wherein said back pressure regulator includes a device comprising a nozzle insert with an outlet flow channel that can receive an outlet flow and an inlet flow channel that can receive an inlet flow, and further includes a seat, connected near an end of said insert, inset from said nozzle insert such that said seat can be in fluidic communication with said outlet flow channel.

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