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Fibronectin based scaffold domain proteins that bind to PCSK9

  • US 8,420,098 B2
  • Filed: 04/13/2011
  • Issued: 04/16/2013
  • Est. Priority Date: 04/13/2010
  • Status: Active Grant
First Claim
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1. An isolated polypeptide comprising a fibronectin type III tenth (10Fn3) domain wherein the 10Fn3 has a BC, DE and FG loop, and wherein the BC loop comprises SEQ ID NO:

  • 14, the DE comprises SEQ ID NO;

    25 and the FG loop comprises SEQ ID NO;

    37, and wherein the polypeptide binds proprotein convertase subtilisin kexin type (PCSK9).

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