Coating with antimicrobial agents

• US 8,420,153 B2
• Filed: 09/19/2008
• Issued: 04/16/2013
• Est. Priority Date: 09/19/2008
• Status: Active Grant

• Current Assignee: Mentor Worldwide LLC (Johnson & Johnson)
• Original Assignee: Mentor Worldwide LLC (Johnson & Johnson)
• Inventors: Berg, Eric P., Stella, Rita
• Primary Examiner(s): Loewe, Robert S
• Application Number:
  US12/233,949
• Publication Number:
  US 20100076113A1
• Time in Patent Office: 1,670 Days
• Field of Search: 523/113
• US Class Current: 427/2.24
• CPC Class Codes: A61L 2300/406 Antibiotics
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: C08L 83/04 Polysiloxanes
• CPC Class Codes: Y10T 428/31663 As siloxane, silicone or silane

Abstract

A coating with antimicrobial agents for use with medical devices. In one approach, a related method involves coating high temperature vulcanized silicone material with a room temperature vulcanized dispersion.

Claims

1. A method for coating a material with active drugs, comprising:

incorporating an active drug into a first material of silicone elastomer that is uncured;

stirring the active drug and the first material of silicone elastomer at 80°

C. until a uniform color and uniform consistency is reached;

forming a coating composition including the active drug and the uncured material;

applying the coating composition to a second cured material of silicone elastomer, wherein the first material is the most external layer, and without swelling the cured silicone elastomer material.

2. The method of claim 1, wherein the first uncured material is an uncured RTV silicone elastomer.

3. The method of claim 2, wherein the second material is a cured HTV silicone elastomer.

4. The method of claim 1, wherein the active drug is one or more of Rifampin and Minocycline.

5. The method of claim 1, comprising coating in an amount to provide an effective concentration to prevent bacterial colonization.

6. The method of claim 5, comprising coating a medical device.

7. The method of claim 6, comprising coating a portion of a breast implant.

8. The method of claim 6, comprising incorporating the active drug into an external layer of a silicone elastomer sheath of the device.

9. The method of claim 1, comprising dissolving or dispersing the active drug into an organic solvent to form an antimicrobial solution or dispersion.

10. The method of claim 9, wherein the organic solvent is one or more of acetic acid and xylene.

11. The method of claim 9, comprising incorporating the antimicrobial solution or dispersion into an uncured RTV silicone elastomer dispersion to form a mixture.

12. The method of claim 11, comprising applying the mixture onto cured HTV silicone elastomer surface of the device.

13. The method of claim 12, comprising curing the uncured silicone elastomer.

14. The method of claim 13, comprising curing for about 60 to 180 minutes at a temperature of 90 to 200 degrees Fahrenheit.