Method to block the infection by flaviviruses, molecules and uses
First Claim
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1. A method for blocking the infection by flaviviruses, said method comprising interfering with the interaction of the viral envelope protein with the alpha-2 macroglobulin receptor identified in the sequence listing as SEQ ID NO:
- 3, wherein the agent that interferes with the interaction of the virus with the receptor is the peptide identified as SEQ ID NO;
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Abstract
The present invention is related to a method for blocking the infection of cells by dengue virus, based on interfering the direct interaction of the viral envelope protein with a cellular receptor or its indirect interaction with said cellular receptor through a carrier protein, as well as related uses; wherein said cellular receptor is the alpha-2 macroglobulin receptor, also known as the low density receptor-related protein or as CD91, and said carrier protein is human alpha-2 macroglobulin.
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8 Claims
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1. A method for blocking the infection by flaviviruses, said method comprising interfering with the interaction of the viral envelope protein with the alpha-2 macroglobulin receptor identified in the sequence listing as SEQ ID NO:
- 3, wherein the agent that interferes with the interaction of the virus with the receptor is the peptide identified as SEQ ID NO;
7. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
- 3, wherein the agent that interferes with the interaction of the virus with the receptor is the peptide identified as SEQ ID NO;
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