Apparatus and method for maintaining and/or restoring viability of organs
First Claim
1. An apparatus for holding an organ for at least one of perfusion, storage, diagnosis and transport of the organ, comprising:
- a portable housing;
a pump; and
an organ supporting surface configured to support an organ within said housing,wherein the pump is connected to at least one first tube directed to a first area of the organ and the pump is connected to at least one second tube directed to a second area of the organ, the at least one first tube having a first flow rate that is controlled differently than a second flow rate of the at least one second tube and the pump at least partially controls both the first and second flow rates differently.
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Abstract
An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.
120 Citations
22 Claims
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1. An apparatus for holding an organ for at least one of perfusion, storage, diagnosis and transport of the organ, comprising:
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a portable housing; a pump; and an organ supporting surface configured to support an organ within said housing, wherein the pump is connected to at least one first tube directed to a first area of the organ and the pump is connected to at least one second tube directed to a second area of the organ, the at least one first tube having a first flow rate that is controlled differently than a second flow rate of the at least one second tube and the pump at least partially controls both the first and second flow rates differently. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. An apparatus for holding an organ for at least one of perfusion, storage, assessment and transport of the organ, comprising:
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a portable housing; a pump; a pump and pulse controller; and an organ supporting surface configured to support an organ within the housing, wherein the pump and pulse controller receives at least one of flow data, tachometer data and pressure data and converts the data into a motor drive wave, the motor drive wave being applied to a pressure wave of the pump to form an output pressure. - View Dependent Claims (10, 11, 12, 13, 14)
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15. An apparatus for holding an organ for at least one of perfusion, storage, diagnosis and transport of the organ, comprising:
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a portable housing; a pump; and an organ supporting surface configured to support an organ within said housing, wherein the pump is connected to at least one first tube directed to a first area of the organ and the pump is connected to at least one second tube directed to a second area of the organ, the at least one first tube having a first pressure that is controlled differently from a second pressure of the at least one second tube and the pump at least partially controls both the first and second pressure differently. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22)
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Specification