Methods of using gamma cyclodextrin to control blood glucose and insulin secretion

• US 8,420,621 B2
• Filed: 06/05/2008
• Issued: 04/16/2013
• Est. Priority Date: 02/19/2004
• Status: Expired due to Fees

• Current Assignee: Abbott Laboratories
• Original Assignee: Abbott Laboratories
• Inventors: Lai, Chron-Si, Chow, JoMay, Wolf, Bryan W.
• Primary Examiner(s): BLAND, LAYLA D
• Application Number:
  US12/133,669
• Publication Number:
  US 20080254100A1
• Time in Patent Office: 1,776 Days
• Field of Search: None
• US Class Current: 514/58
• CPC Class Codes: A23L 2/02 containing fruit or vegetable juices
• CPC Class Codes: A23L 29/35 Degradation products of starch, e.g. hydrolysates, dextrins; Enzymatically modified starches
• CPC Class Codes: A23L 33/10 using additives addition of substantially indigestible substances A23L33/21
• CPC Class Codes: A23P 10/28 Tabletting; Making food bars by compression of a dry powdered mixture
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/328 having effect on glycaemic control and diabetes
• CPC Class Codes: A23V 2200/332 Promoters of weight control and weight loss
• CPC Class Codes: A23V 2250/1644 Milk minerals
• CPC Class Codes: A23V 2250/242 Acesulfame K, acetylsulfame
• CPC Class Codes: A23V 2250/28 Oligosaccharides
• CPC Class Codes: A23V 2250/5054 Gellan
• CPC Class Codes: A23V 2250/5062 Inulin
• CPC Class Codes: A23V 2250/5112 Cyclodextrin
• CPC Class Codes: A23V 2250/5114 Dextrins, maltodextrins
• CPC Class Codes: A23V 2250/54246 Casein
• CPC Class Codes: A23V 2250/54252 Whey protein
• CPC Class Codes: A23V 2250/5432 Gelatine
• CPC Class Codes: A23V 2250/5488 Soybean protein
• CPC Class Codes: A23V 2250/606 Fructose
• CPC Class Codes: A23V 2250/61 Glucose, Dextrose
• CPC Class Codes: A23V 2250/628 : Saccharose, sucrose
• CPC Class Codes: A23V 2250/6406 : Glycerol
• CPC Class Codes: A23V 2250/6416 : Maltitol
• CPC Class Codes: A23V 2250/702 : Vitamin A
• CPC Class Codes: A23V 2250/708 : Vitamin C
• CPC Class Codes: A23V 2250/712 : Vitamin E
• CPC Class Codes: A23V 2250/714 : Vitamin K
• CPC Class Codes: A61K 31/724 : Cyclodextrins
• CPC Class Codes: A61K 9/0056 : Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
• CPC Class Codes: A61K 9/0095 : Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006
• CPC Class Codes: A61P 3/04 : Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 3/10 : for hyperglycaemia, e.g. antidiabetics

Abstract

Disclosed are methods of producing a blunted postprandial glycemic response in an individual, and/or reducing postprandial insulin secretion, said methods comprising administering to the individual a nutritional or other product comprising gamma-cyclodextrin. Also disclosed are similar other methods directed toward the use of such products to provide weight and appetite control, to normalize blood glucose levels in individuals with impaired glucose tolerance, to minimize nighttime hypoglycemia in diabetic and non-diabetic patients, to prevent reactive hypoglycemia in susceptible non-diabetics, to normalize blood glucose levels in individuals with gestational diabetes or impaired glucose tolerance during gestation, and/or to provide a prolonged glycemic response during exercise. The methods are based upon the discovery that gamma-cyclodextrins are rapidly metabolized and absorbed in the small intestine, but subsequently result in a surprisingly blunted postprandial glycemic response and reduced insulin secretion.

Claims

1. A method for producing a blunted postprandial glycemic response in a diabetic individual, said method comprising:

preparing a nutritional product for administration to a diabetic individual, wherein the nutritional product comprises gamma-cyclodextrin and, as a percentage of total calories in the product, from about 10% to about 34% protein, from about 10% to about 40% fat, and from about 24% to 80% carbohydrate inclusive of the gamma-cyclodextrin, wherein from about 5% to 100% by weight of the total carbohydrates in the product is gamma-cyclodextrin; and

administering to the diabetic individual the nutritional product comprising the gamma cyclodextrin.

2. The method of claim 1 wherein the nutritional product is a liquid beverage containing at least about 0.1% gamma-cyclodextrin by weight of the beverage.

3. The method of claim 1 wherein the nutritional product is a liquid beverage containing from about 1% to about 6% gamma-cyclodextrin by weight of the liquid beverage.

4. The method of claim 1 wherein the nutritional product is a solid product containing at least about 1% gamma-cyclodextrin by weight of the solid product.

5. The method of claim 1 wherein the nutritional product is a solid product containing from about 5% to about 10% gamma-cyclodextrin by weight of the solid product.

6. The method of claim 5 wherein the solid product is in bar form.

8. The method of claim 1 wherein the diabetic is afflicted with diabetes mellitus.

9. The method of claim 1 wherein the product is a meal replacement product.

10. The method of claim 1 wherein the product is substantially free of alpha and beta cyclodextrins.

11. The method of claim 1 wherein the method further reduces the occurrence of nighttime hypoglycemia in the diabetic individual, wherein the administering to the diabetic individual the nutritional product comprising the gamma-cyclodextrin comprises administering the nutritional product immediately before bedtime.

7. A method for producing a blunted postprandial glycemic response in a diabetic individual, said method comprising:

preparing a nutritional product for administration to a diabetic individual, wherein the nutritional product comprises gamma-cyclodextrin and, as a percentage of total calories in the product, from about 10% to about 34% protein, from about 10% to about 40% fat, and from about 24% to 80% carbohydrate inclusive of the gamma-cyclodextrin, wherein the gamma-cyclodextrin represents 100% by weight of the total carbohydrates in the product; and

administering to the diabetic individual the nutritional product comprising the gamma cyclodextrin.

12. A method of providing an insulin dependent individual with nutrition while reducing postprandial insulin secretion, said method comprising:

preparing a nutritional product for administration to an insulin dependent individual, wherein the nutritional product comprises gamma-cyclodextrin and, as a percentage of total calories in the product, from about 10% to about 35% protein, from about 10% to about 50% fat, and from about 25% to 80% carbohydrate inclusive of the gamma-cyclodextrin, wherein from about 5% to 100% by weight of the total carbohydrates in the product is gamma-cyclodextrin; and

administering to the insulin dependent individual the nutritional product comprising the gamma cyclodextrin.

13. The method of claim 12 wherein the nutritional product is a liquid beverage containing at least about 0.1% gamma-cyclodextrin by weight of the beverage.

14. The method of claim 12 wherein the nutritional product is a solid product containing at least about 1% gamma-cyclodextrin by weight of the solid product.

15. The method of claim 12 wherein the nutritional product is a solid product containing from about 5% to about 10% gamma-cyclodextrin by weight of the solid product.

17. The method of claim 12 wherein the product is substantially free of alpha and beta cyclodextrins.

16. A method of providing an insulin dependent individual with nutrition while reducing postprandial insulin secretion, said method comprising:

preparing a nutritional product for administration to an insulin dependent individual, wherein the nutritional product comprises gamma-cyclodextrin and, as a percentage of total calories in the product, from about 10% to about 35% protein, from about 10% to about 50% fat, and from about 25% to 80% carbohydrate inclusive of the gamma-cyclodextrin, wherein the gamma-cyclodextrin represents 100% by weight of the total carbohydrates in the product; and

administering to the insulin dependent individual the nutritional product comprising the gamma cyclodextrin.

18. A method of normalizing blood glucose levels in individuals with gestational diabetes or impaired glucose tolerance, said method comprising:

preparing a nutritional product for administration to an individual with gestational diabetes or impaired glucose tolerance, wherein the nutritional product comprises gamma-cyclodextrin and, as a percentage of total calories in the product, from about 5% to about 40% protein, from about 5% to about 35% fat, and from about 5% to 80% carbohydrate inclusive of the gamma-cyclodextrin, wherein from about 5% to 100% by weight of the total carbohydrates in the product is gamma-cyclodextrin; and

administering to the individual with gestational diabetes or impaired glucose tolerance the nutritional product comprising the gamma-cyclodextrin.