Dual electrode system for a continuous analyte sensor
First Claim
Patent Images
1. A continuous glucose sensor configured for insertion into a host'"'"'s tissue, the sensor comprising:
- a first working electrode comprising a first electroactive surface disposed beneath an active enzymatic portion of a sensor membrane, wherein the active enzymatic portion of the sensor membrane is configured to produce H2O2, and wherein the first working electrode is configured to generate a first signal having a first noise component related to a noise-causing species; and
a second working electrode comprising a second electroactive surface disposed beneath an inactive-enzymatic or a non-enzymatic portion of the sensor membrane, wherein the second working electrode is configured to generate a second signal having a second noise component related to the noise-causing species, wherein the first electroactive surface and the second electroactive surface are each dimensioned to integrate at least one signal generated by a plurality of local point sources that produce the noise-causing species, such that the first noise component and the second noise component are substantially equivalent;
wherein each of the first electroactive surface and the second electroactive surface are configured and arranged to integrate noise detected about a circumference of the sensor.
1 Assignment
0 Petitions
Accused Products
Abstract
Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measurement(s) for use in processing sensor data and may be used to trigger events such as digital filtering of data or suspending display of data.
543 Citations
73 Claims
-
1. A continuous glucose sensor configured for insertion into a host'"'"'s tissue, the sensor comprising:
-
a first working electrode comprising a first electroactive surface disposed beneath an active enzymatic portion of a sensor membrane, wherein the active enzymatic portion of the sensor membrane is configured to produce H2O2, and wherein the first working electrode is configured to generate a first signal having a first noise component related to a noise-causing species; and a second working electrode comprising a second electroactive surface disposed beneath an inactive-enzymatic or a non-enzymatic portion of the sensor membrane, wherein the second working electrode is configured to generate a second signal having a second noise component related to the noise-causing species, wherein the first electroactive surface and the second electroactive surface are each dimensioned to integrate at least one signal generated by a plurality of local point sources that produce the noise-causing species, such that the first noise component and the second noise component are substantially equivalent; wherein each of the first electroactive surface and the second electroactive surface are configured and arranged to integrate noise detected about a circumference of the sensor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
-
-
27. A continuous glucose sensor, the sensor comprising:
-
a first working electrode comprising a first electroactive surface disposed beneath an active enzymatic portion of a sensor membrane, wherein the first working electrode is configured to generate a first signal having a first noise component related to a noise-causing species; and a second working electrode comprising a second electroactive surface disposed beneath an inactive-enzymatic or a non-enzymatic portion of the sensor membrane, wherein the second working electrode is configured to generate a second signal having a second noise component related to the noise-causing species; and a physical diffusion barrier configured and arranged to attenuate crosstalk from the active enzymatic portion of the sensor membrane to the second electroactive surface by at least 2-fold. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36)
-
-
37. A continuous glucose sensor configured for insertion into a host and for detecting glucose in the host, the sensor comprising:
-
a first working electrode comprising a first electroactive surface disposed beneath an active enzymatic portion of a sensor membrane, wherein the active enzymatic portion of the membrane is configured to produce a measurable species, wherein the first working electrode is configured to generate a first signal having a first noise component related to a noise-causing metabolic species; a second working electrode comprising a second electroactive surface disposed beneath an inactive-enzymatic or a non-enzymatic portion of the sensor membrane, wherein the second working electrode is configured to generate a second signal having a second noise component related to the noise-causing metabolic species; and a physical diffusion barrier configured and arranged to physically block at least 50% of the measurable species diffusing from the active enzymatic portion of the membrane to the second electroactive surface. - View Dependent Claims (38, 39, 40, 41, 42, 43)
-
-
44. A continuous glucose sensor configured for insertion into a host and for detecting glucose in the host, the sensor comprising:
-
a first working electrode comprising a first electroactive surface disposed beneath an active enzymatic portion of a sensor membrane, wherein the first working electrode is configured to generate a first signal having a first noise component related to a noise-causing species; a second working electrode comprising a second electroactive surface disposed beneath an inactive-enzymatic or a non-enzymatic portion of the sensor membrane, wherein the second working electrode is configured to generate a second signal having a second noise component related to the noise-causing species; a physical diffusion barrier; and an insulator configured to insulate the first working electrode from the second working electrode, wherein the sensor membrane is the insulator. - View Dependent Claims (45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58)
-
-
59. A continuous glucose sensor configured and arranged for insertion into a host and for detecting glucose in the host, the sensor comprising:
-
a first working electrode comprising a first electroactive surface disposed beneath an active enzymatic portion of a sensor membrane, wherein the first electroactive surface is configured to measure a measurable species and generate a first signal having a first noise component related to noise-causing species; a second working electrode comprising a second electroactive surface disposed beneath at least one of an inactive enzymatic portion of the sensor membrane and a non-enzymatic portion of the sensor membrane, wherein the second electroactive surface is configured to generate a second signal having a second noise component related to the noise-causing species; and a physical diffusion barrier disposed between the first working electrode and the second working electrode, wherein the physical diffusion barrier is configured and arranged such that there is substantially no signal associated with crosstalk, wherein the noise-causing species comprises at least one member selected from the group consisting of externally produced H2O2, urea, lactic acid, phosphates, citrates, peroxides, amino acids, amino acid precursors, amino acid break-down products, nitric oxide, NO-donors, NO-precursors, reactive oxygen species, compounds having electroactive acidic, amine or sulfhydryl groups, acetaminophen, ascorbic acid, dopamine, ephedrine, ibuprofen, L-dopa, methyldopa, salicylate, tetracycline, tolazamide, tolbutamide, and triglycerides, wherein the measurable species is H2O2 produced in an active enzymatic portion of a sensor membrane. - View Dependent Claims (60, 61, 62, 63, 64, 65)
-
-
66. A continuous glucose sensor configured and arranged for insertion into a host and for detecting glucose in the host, the sensor comprising:
-
a first working electrode comprising a first electroactive surface disposed beneath an active enzymatic portion of a sensor membrane, wherein the first electroactive surface is configured to measure a measurable species and generate a first signal having a first noise component related to noise-causing species; a second working electrode comprising a second electroactive surface disposed beneath at least one of an inactive enzymatic portion of the sensor membrane and a non-enzymatic portion of the sensor membrane, wherein the second electroactive surface is configured to generate a second signal having a second noise component related to the noise-causing species, and wherein the first electroactive surface and the second electroactive surface are spaced within a crosstalk distance of the measurable species; and a physical diffusion barrier disposed between the first working electrode and the second working electrode, wherein the physical diffusion barrier is configured and arranged such that there is substantially no signal associated with crosstalk, wherein the first electroactive surface has a first area and the second electroactive surface has a second area;
wherein the first area and the second area are dimensioned such that the first noise component and the second noise component are substantially equivalent, wherein the first area and the second area are each configured and arranged to integrate noise detected about a circumference of the sensor.
-
-
67. A continuous glucose sensor configured and arranged for insertion into a host and for detecting glucose in the host, the sensor comprising:
-
a first working electrode comprising a first electroactive surface disposed beneath an active enzymatic portion of a sensor membrane, wherein the first electroactive surface is configured to measure a measurable species and generate a first signal having a first noise component related to noise-causing species; a second working electrode comprising a second electroactive surface disposed beneath at least one of an inactive enzymatic portion of the sensor membrane and a non-enzymatic portion of the sensor membrane, wherein the second electroactive surface is configured to generate a second signal having a second noise component related to the noise-causing species, and wherein the first electroactive surface and the second electroactive surface are spaced within a crosstalk distance of the measurable species; and a physical diffusion barrier disposed between the first working electrode and the second working electrode, wherein the physical diffusion barrier is configured and arranged such that there is substantially no signal associated with crosstalk, wherein the physical diffusion barrier comprises a discontinuous portion of the membrane disposed between the first electroactive surface and the second electroactive surface. - View Dependent Claims (68, 69, 70, 71)
-
-
72. A continuous glucose sensor configured and arranged for insertion into a host and for detecting glucose in the host, the sensor comprising:
-
a first working electrode comprising a first electroactive surface disposed beneath an active enzymatic portion of a sensor membrane, wherein the first electroactive surface is configured to measure a measurable species and generate a first signal having a first noise component related to noise-causing species; a second working electrode comprising a second electroactive surface disposed beneath at least one of an inactive enzymatic portion of the sensor membrane and a non-enzymatic portion of the sensor membrane, wherein the second electroactive surface is configured to generate a second signal having a second noise component related to the noise-causing species, and wherein the first electroactive surface and the second electroactive surface are spaced within a crosstalk distance of the measurable species; and a physical diffusion barrier disposed between the first working electrode and the second working electrode, wherein the physical diffusion barrier is configured and arranged such that there is substantially no signal associated with crosstalk, further comprising an insulator configured to insulate the first working electrode from the second working electrode, wherein the sensor membrane is the insulator. - View Dependent Claims (73)
-
Specification