Efficient dynamic stimulation in an implanted device

• US 8,423,132 B2
• Filed: 12/11/2003
• Issued: 04/16/2013
• Est. Priority Date: 12/12/2002
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: BioControl Medical (B.C.M) Ltd.
• Inventors: Vaingast, Shai, Cohen, Ehud
• Primary Examiner(s): STOKLOSA, JOSEPH A
• Application Number:
  US10/538,521
• Publication Number:
  US 20060265027A1
• Time in Patent Office: 3,414 Days
• Field of Search: 607/28, 607/52, 607/2, 607/8
• US Class Current: 607/2
• CPC Class Codes: A61N 1/36142 for improving safety
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/37 Monitoring; Protecting
• CPC Class Codes: A61N 1/3716 with reduction of residual polarisation effects

Abstract

A method for measuring impedance of a tissue (20), consisting of charging a capacitor (C15) to a potential, and discharging the capacitor for a discharge period through the tissue. The method further consists of measuring a voltage drop on the capacitor over the discharge period and determining the impedance of the tissue responsive to the potential, the voltage drop, and the discharge period.

Claims

1. Apparatus for stimulating tissue having a capacitance, comprising:

charge circuitry which is adapted to apply a stimulation current to the tissue, causing a voltage to develop across the capacitance of the tissue; and

discharge circuitry which is adapted to inject a discharge current to the tissue so as to discharge the capacitance, such that, while the discharge current is being injected into the tissue, a value of the discharge current is substantially independent of the voltage across the capacitance,

the discharge circuitry being adapted to measure the voltage across the capacitance, and to halt injection of the discharge current to the tissue when the voltage is substantially zero.

2. Apparatus according to claim 1, wherein the charge circuitry comprises a stimulation capacitor, an inductor, and a micro-controller which is adapted to apply pulses having a variable duty cycle to the inductor, and wherein the micro-controller causes the inductor to charge the stimulation capacitor to the voltage by altering the variable duty cycle.

3. Apparatus according to claim 1, wherein the discharge circuitry is adapted to inject the discharge current to the tissue, by injecting into the tissue a discharge current that is substantially fixed.

4. Apparatus according to claim 1, comprising a micro-controller which is adapted to measure a time to discharge the capacitance, and to generate a measure of the capacitance in response to the time.

5. Apparatus according to claim 1, comprising a micro-controller which is adapted to measure a time to apply the stimulation current to the tissue, and to generate a measure of the capacitance in response to the time.

6. Apparatus according to claim 1, wherein the discharge circuitry is adapted to inject the discharge current, the discharge current having a value that substantially eliminates anodal break excitation of the tissue.

7. Apparatus according to claim 1, and comprising:

a battery having a first battery terminal and a second battery terminal coupled to ground and generating a battery voltage which powers at least a first part of the charge circuitry and at least a second part of the discharge circuitry; and

a first and a second stimulation electrode between which the capacitance is formed,

wherein the first battery terminal and the first stimulation electrode are connected, and

wherein the charge circuitry causes the voltage to develop between the first and the second stimulation electrodes, and

wherein the discharge circuitry injects the discharge current between the first and the second stimulation electrodes.

8. Apparatus according to claim 7, and comprising:

a stimulation capacitor which receives a stimulation voltage generated by the charge circuitry; and

a detector which monitors a second-stimulation-electrode potential on the second stimulation electrode,

the detector being coupled between ground and the stimulation potential.

9. Apparatus according to claim 8, and comprising a micro-controller which receives a Boolean signal from the detector in response to the second-stimulation-electrode potential, and which modifies a targeted voltage for the voltage across the stimulation capacitor, in response thereto.

10. A method for stimulating tissue having a capacitance, comprising:

applying a stimulation current to the tissue so as to cause a voltage to develop across the capacitance of the tissue;

injecting a discharge current to the tissue so as to discharge the capacitance, such that, while the discharge current is being injected into the tissue, a value of the discharge current is substantially independent of the voltage across the capacitance;

measuring the voltage across the capacitance; and

halting injection of the discharge current to the tissue when the voltage is substantially zero.

11. A method according to claim 10, wherein injecting the discharge current comprises injecting a discharge current that is substantially fixed.

12. A method according to claim 10, and comprising measuring a time to discharge the capacitance, and generating a measure of the capacitance in response to the time.

13. A method according to claim 10, and comprising measuring a time to apply the stimulation current to the tissue, and generating a measure of the capacitance in response to the time.

14. A method according to claim 10, wherein injecting the discharge current comprises injecting the discharge current, the value of the discharge current substantially eliminating anodal break excitation of the tissue.

15. A method according to claim 10, and comprising:

providing a battery having a first battery terminal and a second battery terminal coupled to ground;

providing a first and a second stimulation electrode between which the capacitance is formed;

connecting the first battery terminal and the first stimulation electrode;

causing the voltage to develop between the first and the second stimulation electrodes;

injecting the discharge current between the first and the second stimulation electrodes;

providing a stimulation capacitor which receives a stimulation voltage in response to applying the stimulation current;

coupling a detector between ground and the stimulation potential; and

monitoring with the detector a second-stimulation-electrode potential on the second stimulation electrode.

16. A method according to claim 15, and comprising:

receiving a Boolean signal from the detector in response to the second-stimulation-electrode potential;

setting a targeted voltage for the voltage across the stimulation capacitor; and

modifying the targeted voltage in response to the signal.