Cross-checking of transthoracic impedance and acceleration signals

• US 8,423,142 B2
• Filed: 10/31/2011
• Issued: 04/16/2013
• Est. Priority Date: 12/30/2002
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Freeberg, Scott
• Primary Examiner(s): Holmes, Rex R
• Application Number:
  US13/285,560
• Publication Number:
  US 20120046559A1
• Time in Patent Office: 533 Days
• Field of Search: 607 4- 28, 607/42, 600500-519, 600/529, 600/547
• US Class Current: 607/42
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters

Abstract

A first chamber minute ventilation rate is determined based on a first transthoracic impedance signal received from a first chamber of a heart and a second chamber minute ventilation rate is determined based on a second transthoracic impedance signal received from a second chamber of the heart. A processor compares the minute ventilation rates to determine a rate. In one embodiment, an accelerometer sensor provides data for evaluating propriety of a rate. Before implementing a rate change, signals from multiple sensors are cross-checked.

Claims

1. An implantable system configured to be coupled to a heart having a first chamber and a second chamber, the system comprising:

a first impedance sensor configured to measure a first impedance associated with the first chamber;

a second impedance sensor configured to measure a second impedance associated with the second chamber; and

a processor coupled to the first impedance sensor and the second impedance sensor, the processor configured to determine a first ventilation rate using the first impedance, determine a second ventilation rate using the second impedance, and compare the first ventilation rate to the second ventilation rate to determine a difference between the first ventilation rate and the second ventilation rate.

2. The system of claim 1, further comprising an activity sensor coupled to the processor, the activity sensor configured to sense an activity signal indicative of physical activity, and wherein the processor is configured to select one of the first impedance and the second impedance using the activity signal and the difference between the first ventilation rate and the second ventilation rate.

3. The system of claim 2, wherein the activity sensor comprises an accelerometer.

4. The system of claim 3, further comprising a therapy circuit coupled to the processor, the therapy circuit configured to deliver a therapy to the heart, and wherein the processor is configured to control the delivery of the therapy using the selected one of the first impedance and the second impedance.

5. The system of claim 4, wherein the therapy circuit comprises a pulse generator.

6. The system of claim 1, further comprising a therapy circuit coupled to the processor, and wherein the processor is configured to provide a first therapy signal to the therapy circuit in response to the first ventilation rate not being substantially different from the second ventilation rate and provide a second therapy signal to the therapy circuit in response to the first ventilation rate being substantially different from the second ventilation rate, and the therapy circuit is configured to deliver a first therapy regimen in response to the first therapy signal and a second therapy regimen in response to the second therapy signal.

7. The system of claim 1, further comprising a first accelerometer coupled to the processor, the first accelerometer configured to sense a first acceleration signal, and wherein the processor is configured to select one of the first ventilation rate and the second ventilation rate using the first acceleration signal in response to the difference between the first ventilation rate and the second ventilation rate being substantial.

8. The system of claim 7, wherein the processor is configured to select one of the first ventilation rate and the second ventilation rate by cross checking the first ventilation rate and the second ventilation rate with the first acceleration signal.

9. The system of claim 8, wherein the first accelerometer has a first axis of sensitivity, and further comprising a second accelerometer coupled to the processor, the second accelerometer configured to sense a second acceleration signal and having a second axis of sensitivity intersecting the first axis, and wherein the processor is configured to select one of the first ventilation rate and the second ventilation rate by cross checking the first ventilation rate and the second ventilation rate with the first acceleration signal and the second acceleration signal.

10. The system of claim 1, further including a therapy circuit coupled to the processor, the therapy circuit configured to deliver a therapy to the heart, and wherein the processor is configured to control the delivery of the therapy using the difference between the first ventilation rate and the second ventilation rate.

11. A method, comprising:

measuring a first impedance associated with a first chamber of a heart;

measuring a second impedance associated with a second chamber of the heart;

determining a first ventilation rate using the first impedance;

determining a second ventilation rate using the second impedance;

comparing the first ventilation rate to the second ventilation rate; and

adjusting a therapy using an outcome of the comparison of the first ventilation rate to the second ventilation rate.

12. The method of claim 11, wherein adjusting the therapy comprises adjusting a pacing therapy.

13. The method of claim 12, further comprising determining a difference between the first ventilation rate and the second ventilation rate, and wherein adjusting the pacing therapy comprises adjusting a pacing rate using the difference between the first ventilation rate and the second ventilation rate.

14. The method of claim 11, further including:

sensing an activity signal; and

selecting one of the first impedance and the second impedance using the activity signal in response to the outcome of the comparison indicating that the first ventilation rate is substantially different from the second ventilation rate.

15. The method of claim 14, wherein sensing the activity signal comprises sensing a first acceleration signal using a first accelerometer.

16. The method of claim 15, further comprising:

cross checking the first ventilation rate and the second ventilation rate with the first acceleration signal; and

selecting one of the first ventilation rate and the second ventilation rate using an outcome of the cross checking.

17. The method of claim 16, further comprising:

sensing a second acceleration signal using a second accelerometer;

cross checking the first ventilation rate and the second ventilation rate with the first acceleration signal and the second acceleration signal; and

selecting one of the first ventilation rate and the second ventilation rate using an outcome of the cross checking.

18. A method, comprising:

sensing a first acceleration signal indicative of activity of a heart using a first accelerometer;

sensing a second acceleration signal indicative of activity of the heart using a second accelerometer;

determining whether the first acceleration signal is substantially different from the second acceleration signal;

delivering a first therapy regimen to the heart in response to the first acceleration signal not being substantially different from the second acceleration signal;

sensing an impedance signal indicative of ventilation;

delivering a second therapy regimen to the heart in response to the first acceleration signal being substantially different from the second acceleration signal, the second therapy regimen selected as a function of the impedance signal.

19. The method of claim 18, wherein sensing the first acceleration signal and sensing the second acceleration signal comprise using a first accelerometer having a first axis of sensitivity and a second accelerometer having a second axis of sensitivity that intersects the first axis of sensitivity.

20. The method of claim 19, wherein determining whether the first acceleration signal is substantially different from the second acceleration signal comprises calculating a correlation coefficient.