Dry powder inhaler and system for drug delivery
First Claim
1. A dry powder medicament cartridge for an inhaler, comprising:
- an enclosure configured to hold a medicament comprising a cartridge top and a cartridge bottom which are moveable relative to one another by a translational motion;
at least one inlet port to allow flow into the enclosure, andat least one dispensing port to allow flow out of the enclosure;
said at least one inlet port is configured to direct at least a portion of the flow entering theat least one inlet port at the at least one dispensing port within the enclosure in response to a pressure differential.
7 Assignments
0 Petitions
Accused Products
Abstract
A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.
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Citations
71 Claims
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1. A dry powder medicament cartridge for an inhaler, comprising:
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an enclosure configured to hold a medicament comprising a cartridge top and a cartridge bottom which are moveable relative to one another by a translational motion; at least one inlet port to allow flow into the enclosure, and at least one dispensing port to allow flow out of the enclosure; said at least one inlet port is configured to direct at least a portion of the flow entering the at least one inlet port at the at least one dispensing port within the enclosure in response to a pressure differential. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A dry powder medicament cartridge for a dry powder inhaler, comprising:
- a cartridge top and a cartridge bottom defining an internal volume;
wherein the cartridge top or the cartridge bottom are moveable relative to one another by a translational motion;
wherein the cartridge top has an undersurface that extends over the cartridge bottom;
said undersurface configured to engage said cartridge bottom, and having an area to seal the internal volume and an area to expose the internal volume to ambient air. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
- a cartridge top and a cartridge bottom defining an internal volume;
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37. A dry powder medicament cartridge for a dry powder inhaler, comprising a cartridge top and a cartridge bottom;
- the cartridge top configured relatively flat and having one or more openings and one or side panels having tracks configured to engage the cartridge bottom;
wherein the cartridge top has an undersurface configured to have a relatively flat surface and provide closure of the internal volume at one end and to provide a flow conduit at the opposing end;
said cartridge bottom having an inner surface defining an internal volume and is moveably attached to the tracks on the one or more side panels on the cartridge top and configurable to attain a containment position and a dispensing or dosing position by moving along the tracks of the one or more side panels. - View Dependent Claims (38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 50, 51, 52, 53, 54, 55, 56)
- the cartridge top configured relatively flat and having one or more openings and one or side panels having tracks configured to engage the cartridge bottom;
- 49. A dry powder medicament cartridge for an inhaler, comprising an enclosure comprising a cartridge top and a cartridge bottom which are moveable relative to one another by a translational motion and having one or more exit ports configured to have a smallest dimension less than 3 mm to exclude release of larger powder aggregates.
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62. A dry powder medicament cartridge for an inhaler comprising:
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a substantially flat cartridge top, arrow-like in configuration, having one or more dispensing apertures, and two side panels extending downwardly and each of the two side panels having a track; and a cartridge bottom moveably engaged to the track of the side panels of the cartridge top, and comprising a chamber configured having a relatively cup-like shape with two relatively flat and parallel sides and a relatively rounded bottom, and interior surface defining an internal volume, which promotes tumbling of a flow entering the internal volume;
said container configurable to attain a containment position and a dosing position with said cartridge topwherein the cartridge top and the cartridge bottom are moveable relative to one another by a translational motion. - View Dependent Claims (63, 64, 65, 66, 67, 68, 69, 70, 71)
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Specification