Device and method for modulating renal function
First Claim
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1. A device, comprising:
- a controller contained within an implantable housing;
a physiological sensor interfaced to the controller for measuring a physiological variable; and
,an occluding structure adapted for implantation within a renal lymphatic vessel and operable by the controller to occlude the renal lymphatic vessel and thereby restrict flow therethrough;
wherein the occluding structure comprises a catheter incorporating an expandable balloon adapted for disposition in the renal lymphatic vessel and a pressurized fluid source for expanding the balloon operable by the controller;
a transthoracic impedance sensor for detecting pulmonary edema; and
,wherein the controller is programmed to operate the occluding structure in response to the measured physiological variable and further programmed to operate the occluding structure if pulmonary edema is detected.
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Abstract
Renal function may be modulated by an implantable device having one or more leads or catheters disposed near the kidney via the lymphatic system. In one embodiment, lymphatic drainage from the kidney is modulated to increase or decrease tubular reabsorption of salt and water. The renal function modulation therapy may be delivered in an open-loop or closed-loop fashion, with the latter dependent upon a physiological variable such as blood pressure or cardiac output.
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Citations
18 Claims
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1. A device, comprising:
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a controller contained within an implantable housing; a physiological sensor interfaced to the controller for measuring a physiological variable; and
,an occluding structure adapted for implantation within a renal lymphatic vessel and operable by the controller to occlude the renal lymphatic vessel and thereby restrict flow therethrough; wherein the occluding structure comprises a catheter incorporating an expandable balloon adapted for disposition in the renal lymphatic vessel and a pressurized fluid source for expanding the balloon operable by the controller; a transthoracic impedance sensor for detecting pulmonary edema; and
,wherein the controller is programmed to operate the occluding structure in response to the measured physiological variable and further programmed to operate the occluding structure if pulmonary edema is detected. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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Specification