Self-encoding sensor with microspheres
First Claim
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1. A method of detecting an analyte, said method comprising:
- (a) providing a planar array comprising a population of sensor elements at a density of at least 20,000 sensor elements per 1 mm2, said population of sensor elements comprising different subpopulations of redundant sensor elements;
(b) contacting said array with an analyte under conditions wherein said analyte binds to redundant sensor elements in at least one subpopulation of sensor elements, thereby producing signals at separate redundant sensor elements;
(c) detecting each of said signals generated from said separate redundant sensor elements in said at least one subpopulation of redundant sensor elements; and
(d) combining each of the signals detected from said separate redundant sensor elements wherein said signals indicate the presence of said analyte, and wherein all said signals comprise optical signals, or non-optical signals generated by the separate redundant sensor elements.
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Abstract
Disclosed herein are compositions and methods for combining the output obtained from redundant sensor elements in a sensor array.
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Citations
30 Claims
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1. A method of detecting an analyte, said method comprising:
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(a) providing a planar array comprising a population of sensor elements at a density of at least 20,000 sensor elements per 1 mm2, said population of sensor elements comprising different subpopulations of redundant sensor elements; (b) contacting said array with an analyte under conditions wherein said analyte binds to redundant sensor elements in at least one subpopulation of sensor elements, thereby producing signals at separate redundant sensor elements; (c) detecting each of said signals generated from said separate redundant sensor elements in said at least one subpopulation of redundant sensor elements; and (d) combining each of the signals detected from said separate redundant sensor elements wherein said signals indicate the presence of said analyte, and wherein all said signals comprise optical signals, or non-optical signals generated by the separate redundant sensor elements. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A method of detecting signals produced at sensor elements of an array, said method comprising:
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(a) providing planar array comprising a population of sensor elements at a density of at least 20,000 sensor elements per 1 mm2, said population of sensor elements comprising different subpopulations of redundant sensor elements, each of said redundant sensor elements comprising a well that includes not more than one bead having nucleic acids attached thereto; (b) contacting the array with an analyte so as to produce signals at separate redundant sensor elements in at least one subpopulation of sensor elements; (c) detecting each of said signals generated from said separate redundant sensor elements in at least one subpopulation of redundant sensor elements; and (d) combining each of the signals detected from said separate redundant sensor elements wherein all said signals comprise optical signals or non-optical signals generated by the separate redundant sensor elements. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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Specification