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Use of medium chain triglycerides for the treatment and prevention of alzheimer'S disease and other diseases resulting from reduced neuronal metabolism

  • US 8,426,468 B2
  • Filed: 04/12/2012
  • Issued: 04/23/2013
  • Est. Priority Date: 05/01/2000
  • Status: Expired due to Term
First Claim
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1. A method of treating loss of cognitive function caused by reduced neuronal metabolism, wherein said treatment comprises oral administration of a dosage unit of medium chain triglyceride to a patient such that the blood level of D-beta-hydroxybutyrate in the patient is raised to about 1-10 mM or patient urinary excretion of D-beta-hydroxybutyrate is in the range 5 mg/dL to 160 mg/dL causing hyperketonemia in the patient, wherein the patient has a diet wherein carbohydrate intake is not restricted, resulting in ketone bodies being utilized for energy in the brain.

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