Methods and compositions for reducing body fat and adipocytes

• US 8,426,471 B1
• Filed: 07/13/2012
• Issued: 04/23/2013
• Est. Priority Date: 12/19/2011
• Status: Active Grant

• Current Assignee: Topokine Therapeutics, Inc. (Abbvie Incorporated)
• Original Assignee: Topokine Therapeutics, Inc. (Abbvie Incorporated)
• Inventors: Singer, Michael S., Kalayoglu, Murat V.
• Primary Examiner(s): RAO, SAVITHA M
• Application Number:
  US13/548,482
• Time in Patent Office: 284 Days
• Field of Search: 514/573, 514/405, 514/255.05, 514/236.5, 514/378, 514/341, 514/26, 514/177, 514/117, 544/405, 544/140, 548/247, 548/364.1, 548/374.1
• US Class Current: 514/573
• CPC Class Codes: A61K 31/165 having aromatic rings, e.g. colchicine, atenolol, progabide
• CPC Class Codes: A61K 31/191 having two or more hydroxy groups, e.g. gluconic acid
• CPC Class Codes: A61K 31/216 of acids having aromatic rings, e.g. benactizyne, clofibrate
• CPC Class Codes: A61K 31/25 with polyoxyalkylated alcohols, e.g. esters of polyethylene glycol
• CPC Class Codes: A61K 31/5575 having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
• CPC Class Codes: A61K 8/69 containing fluorine
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears
• CPC Class Codes: A61K 9/06 Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels composition of ointments, creams or gels A61K47/00
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 3/06 Antihyperlipidemics
• CPC Class Codes: A61Q 19/005 Preparations for sensitive skin
• CPC Class Codes: A61Q 19/06 for countering cellulitis

Abstract

Provided are methods of reducing body fat in a subject, comprising locally (e.g., topically) administering one or more compounds of the Formula (I):

or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, polymorph, tautomer, isotopically enriched derivative, or prodrug thereof, wherein X is —OR₁, —SR₂, or —NR₃R₄, and R₁, R₂, R₃, and R₄ are as defined herein.

Claims

1. A method for reducing fat in a body of a subject in need thereof, the method comprising administering to the skin of the subject a composition comprising less than 1% by weight of a compound of the formula:

2. The method of claim 1, wherein the compound is:

3. The method of claim 1, wherein the subject suffers from obesity.

4. The method of claim 1, wherein the subject suffers from gynecomastia.

5. The method of claim 1, wherein the subject suffers from HIV lipodystrophy.

6. The method of claim 1, wherein the subject suffers from lipoma.

7. The method of claim 1, wherein the subject suffers from excess fat on the chin.

8. The method of claim 1, wherein the route of said administering is topical.

9. The method of claim 1, wherein the route of said administering is selected from the group consisting of subcutaneous, intradermal, and intralesional.

10. The method of claim 1, wherein the administering is to a body part selected from the group consisting of the abdomen, chest, breast, buttocks, hips, thighs, legs, knees, arms, chin, neck, and face.