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Method and composition for administering an NMDA receptor antagonist to a subject

  • US 8,426,472 B2
  • Filed: 10/28/2011
  • Issued: 04/23/2013
  • Est. Priority Date: 11/23/2004
  • Status: Active Grant
First Claim
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1. A method of administering memantine to a human subject in need thereof, comprising:

  • orally administering to the subject once per day over multiple days a sustained release oral dosage form comprising memantine or a pharmaceutically acceptable salt thereof and a component that sustains release of the memantine or the salt thereof;

    wherein a daily dose of 12.5 to 40 mg of memantine or pharmaceutically acceptable salt thereof is administered from the initiation of therapy without prior dose escalation of memantine;

    wherein such administration results in the subject achieving a therapeutically effective steady state memantine plasma concentration within 20 days after initiation of therapy with said dosage form; and

    wherein the subject has a condition selected from the group consisting of Alzheimer'"'"'s disease, dementia, Parkinson'"'"'s disease and neuropathic pain.

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