Multimode cells and methods of using them
First Claim
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1. A system configured to permit switching of a cell between at least two modes comprising a collision mode and a reaction mode, the system comprising:
- a cell configured to receive a collision gas in a collision mode to pressurize the cell and configured to receive a reaction gas in a reaction mode to pressurize the cell, the cell comprising a quadrupole rod set; and
a controller electrically coupled to the quadrupole rod set of the cell and configured to provide a waveform from a voltage source to the quadrupole set to provide a quadrupolar field within the cell, the controller configured to provide an effective voltage from the voltage source to the cell in the collision mode to select ions comprising an energy greater than a barrier energy and an effective voltage from the voltage source in the reaction mode to select ions using mass filtering.
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Abstract
A mass spectrometer is provided that is configurable for operation in both a Kinetic Energy Discrimination (KED) mode and a dynamic reaction cell (DRC) mode. To operate in the KED mode, a collision cell can be filled with a quantity of the inert gas, and an energy barrier can be formed between the collision cell and a downstream mass analyzer. To operate instead in the DRC mode, the collision cell can be filled with a quantity of gas that is reactive with the interferer ions.
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Citations
28 Claims
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1. A system configured to permit switching of a cell between at least two modes comprising a collision mode and a reaction mode, the system comprising:
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a cell configured to receive a collision gas in a collision mode to pressurize the cell and configured to receive a reaction gas in a reaction mode to pressurize the cell, the cell comprising a quadrupole rod set; and a controller electrically coupled to the quadrupole rod set of the cell and configured to provide a waveform from a voltage source to the quadrupole set to provide a quadrupolar field within the cell, the controller configured to provide an effective voltage from the voltage source to the cell in the collision mode to select ions comprising an energy greater than a barrier energy and an effective voltage from the voltage source in the reaction mode to select ions using mass filtering. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method of switching a quadrupolar cell between a collision mode and a reaction mode, the method comprising:
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introducing a first ion stream into the quadrupolar cell, the cell configured to receive a collision gas in a collision mode to pressurize the cell and configured to receive a reaction gas in a reaction mode to pressurize the cell, the cell comprising a quadrupole rod set operative to provide a quadrupolar field within the cell; selecting ions comprising an energy greater than a barrier energy from the introduced first ion stream by introducing a collision gas into the cell in the collision mode, the cell comprising a voltage effective to permit selection of the ions comprising the energy greater than the barrier energy; exhausting the introduced first ion stream and the introduced collision gas from the cell; introducing a second ion stream into the cell; and selecting ions using mass filtering from the introduced second ion stream by introducing a reaction gas in the reaction mode, the cell comprising a voltage effective to permit selection of the ions using the mass filtering. - View Dependent Claims (19, 20, 21, 22, 23)
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24. A method of switching a quadrupolar cell between a reaction mode and a collision mode, the method comprising:
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introducing a first ion stream into the quadrupolar cell, the cell configured to receive a collision gas in a collision mode to pressurize the cell and configured to receive a reaction gas in a reaction mode to pressurize the cell, the cell comprising a quadrupole rod set operative to provide a quadrupolar field within the cell; selecting ions using mass filtering from the introduced first ion stream by introducing a reaction gas in the reaction mode, the cell comprising a voltage effective to permit selection of the ions using the mass filtering; exhausting the introduced first ion stream and the introduced reaction gas from the cell; introducing a second ion stream into the cell; and selecting ions comprising an energy greater than a barrier energy from the introduced second ion stream by introducing a collision gas into the cell in the collision mode, the cell comprising a voltage effective to permit selection of the ions comprising the energy greater than the barrier energy. - View Dependent Claims (25, 26, 27, 28)
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Specification