Retinal prosthesis techniques

• US 8,428,740 B2
• Filed: 08/06/2010
• Issued: 04/23/2013
• Est. Priority Date: 08/06/2010
• Status: Active Grant

• Current Assignee: Nano-Retina Inc.
• Original Assignee: Nano-Retina Inc.
• Inventors: Gefen, Ra'anan, Liran, Tuvia
• Primary Examiner(s): Koharski, Christopher D
• Assistant Examiner(s): CAREY, MICHAEL JAMES
• Application Number:
  US12/852,218
• Publication Number:
  US 20120035725A1
• Time in Patent Office: 991 Days
• Field of Search: 607/54, 607/53, 623/6.63
• US Class Current: 607/54
• CPC Class Codes: A61N 1/0543 Retinal electrodes
• CPC Class Codes: A61N 1/36046 of the eye
• CPC Class Codes: A61N 1/3787 from an external energy source

Abstract

Apparatus is provided including an external device including, a mount, which is placed in front of an eye of a subject. A power source is coupled to the mount and emits energy toward the eye. An intraocular device is implanted entirely in the subject'"'"'s eye, and includes a control unit, a plurality of stimulating electrodes, and an energy receiver, which receives the energy from the power source and generates a voltage drop in response. A plurality of photosensors detect photons and generate a signal in response. Driving circuitry is coupled to the energy receiver and to the photosensors, and drives the electrodes to apply electrical charges to a retina in response to the signals from the photosensors. The external device modulates the emitted energy, and the control unit demodulates the modulated energy to regulate an operation parameter of the intraocular device. Other embodiments are also described.

Claims

1. Apparatus configured for implantation in a body of a subject, comprising:

an implantable array of at least 10 subsets of 3 or more electrodes; and

for each subset, a respective power supply configured to provide current to the electrodes in the subset,

wherein at least some of the electrodes in each subset are configured to drive respective electrical charges into tissue of the subject.

2. The apparatus according to claim 1, wherein the respective power supply for each subset comprises a common capacitor for the subset.

3. The apparatus according to claim 1, wherein the at least 10 subsets comprise 10-2500 subsets.

4. The apparatus according to claim 1, wherein a total volume of the apparatus is less than 0.2 cc.

5. The apparatus according to claim 1, wherein an electrode in at least one of the subsets is within 500 um of another electrode in the subset.

6. The apparatus according to claim 1, wherein an electrode in at least one of the subsets is within 300 um of another electrode in the subset.

7. Apparatus, comprising:

an external device, comprising;

a mount, configured to be placed in front of an eye of a subject; and

a power source coupled to the mount and configured to emit energy toward the eye; and

an intraocular device configured to be implanted entirely in the subject'"'"'s eye, the intraocular device comprising;

a light receiving element configured to switch between;

a first time period, during which the light receiving element receives the energy from the power source and generates a voltage drop in response thereto; and

a second time period, during which the light receiving element detects photons and generates a signal in response thereto;

a control unit configured to regulate the switch between the first and second time periods;

a plurality of stimulating electrodes; and

driving circuitry, coupled to the light receiving element, and configured to utilize the voltage drop to drive the electrodes to apply electrical charges to a retina of the eye in response to the signal from the light receiving element.

19. The apparatus according to claim 7, wherein the intraocular device further comprises a charge pump configured to generate a voltage to be supplied to at least one component of the intraocular device.

8. Apparatus configured for implantation in an eye of a subject, comprising:

an intraocular device comprising;

a plurality of photosensors, each photosensor configured to detect photons and to generate a signal in response thereto;

an array of at least 10 subsets of two or more electrodes; and

a control unit, configured to drive at least some of the electrodes in each subset to non-simultaneously apply respective electrical charges into a retina of the subject, in response to photons detected generally simultaneously by respective ones of the photosensors.

9. The apparatus according to claim 8, wherein the control unit is configured such that the electrical charge driven by each electrode in a subset is returned via a plurality of the other electrodes in the subset.

10. The apparatus according to claim 8, wherein the control unit is configured such that the electrical charge driven by each electrode in a subset is returned via all of the other electrodes in the subset.

11. The apparatus according to claim 8, wherein the control unit is configured such that the electrical charge driven by each electrode in a subset is returned via an electrode in the subset that serves as a common return electrode for the other electrodes in the subset.

12. Apparatus, comprising:

an external device, comprising;

a mount, configured to be placed in front of an eye of a subject; and

a power source coupled to the mount and configured to emit energy toward the eye; and

an intraocular device configured to be implanted entirely in the subject'"'"'s eye, the intraocular device comprising a die comprising;

an energy receiver, configured to receive the energy from the power source and to generate a voltage drop in response thereto; and

a plurality of photosensors, each photosensor configured to detect photons and to generate a signal in response thereto,

wherein the intraocular device further comprises an additional die, the additional die comprising;

a plurality of stimulating electrodes; and

driving circuitry, coupled to the energy receiver and to the photosensors, and configured to utilize the voltage drop to drive the electrodes to apply electrical charges to a retina of the eye in response to the signals from the photosensors,

the additional die being sized such that the plurality of stimulating electrodes is configured to cover an area of the retina that is larger than an area of the plurality of photosensors.

13. The apparatus according to claim 12, wherein the die that comprises the energy receiver and the plurality of photosensors further comprises a charge pump configured to generate a voltage to be supplied to at least one component of the intraocular device.

14. The apparatus according to claim 12, wherein the external device is configured to modulate the energy emitted from the power source, and wherein the die that comprises the energy receiver and the plurality of photosensors comprises a control unit configured to demodulate the modulated energy and, in response, regulate an operation parameter of the intraocular device.

15. The apparatus according to claim 12, wherein the external device is configured to modulate the energy emitted from the power source, and wherein the die that comprises the energy receiver and the plurality of photosensors further comprises a demodulator configured to demodulate the modulated energy and, in response, regulate an operation parameter of the intraocular device.

16. The apparatus according to claim 12, wherein the additional die further comprises a charge pump configured to generate a voltage to be supplied to the intraocular device.

17. The apparatus according to claim 12, wherein the external device is configured to modulate the energy emitted from the power source, and wherein the additional die comprises a control unit configured to demodulate the modulated energy and, in response, regulate an operation parameter of the intraocular device.

18. The apparatus according to claim 12, wherein the external device is configured to modulate the energy emitted from the power source, and wherein the additional die further comprises a demodulator configured to demodulate the modulated energy and, in response, regulate an operation parameter of the intraocular device.