Nerve cuff, method and apparatus for manufacturing same

• US 8,428,749 B2
• Filed: 06/01/2012
• Issued: 04/23/2013
• Est. Priority Date: 06/02/2006
• Status: Active Grant

• Current Assignee: 4491343 Canada Inc.
• Original Assignee: Neurostream Technologies General Partnership
• Inventors: Hoffer, Joaquin Andres, Imbeau, Marc-Olivier, Vallieres, Jean-Martin
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): Stice, Paula J
• Application Number:
  US13/486,864
• Publication Number:
  US 20120233855A1
• Time in Patent Office: 326 Days
• Field of Search: 607/118, 264/259, 264/271.1, 264/279.1, 264/229
• US Class Current: 607/118
• CPC Class Codes: A61N 1/0556 Cuff electrodes
• CPC Class Codes: B29C 39/10 incorporating preformed parts or layers, e.g. casting around inserts or for coating articles coating a surface by casting in general B05D1/30, B29C39/126 takes precedence
• CPC Class Codes: B29C 45/14426 Coating the end of wire-like or rod-like or cable-like or blade-like or belt-like articles
• CPC Class Codes: Y10T 29/49117 Conductor or circuit manufacturing

Abstract

A nerve cuff comprising a wall band member having an inner surface defining a lumen when the wall band member is in a closed configuration for receiving a nerve therethrough. At least one longitudinal and contiguous conductor extends within the lumen. The conductor is insulated and has at least one exposed portion thereby providing an electrode. When mounting the nerve cuff to a nerve, each electrode is in electrical communication with the nerve. A multi-channel nerve cuff further comprises a plurality of longitudinal ridges formed on the inner surface with each adjacent pair of ridges defining a longitudinal chamber. Each chamber comprises a respective conductor extending therein. When mounting the multi-channel nerve cuff to the nerve, the ridges abut the nerve providing for each chamber to isolate respective longitudinal portions of the nerve. A method and an apparatus for manufacturing such nerve cuffs are also disclosed.

Claims

1. A method of manufacturing a nerve cuff, the method comprising the steps of:

(a) providing a mold comprising a plurality of longitudinal grooves;

(b) positioning one of a plurality of longitudinal conductors coated with insulation within each longitudinal groove;

(c) applying flexible bio-compatible material on the mold with the plurality of longitudinal conductors positioned therein;

(d) curing the flexible bio-compatible material so as to provide a wall band member with the plurality of longitudinal conductors adhered thereto;

(e) ejecting the wall band member with the adhered plurality of longitudinal conductors; and

(f) removing at least one portion of the insulation on the plurality of longitudinal conductors to provide electrodes, wherein each of the at least one portions is situated between a proximal end and a distal end of each longitudinal conductor.

2. The method of claim 1, wherein step (b) further comprises positioning one of a plurality of longitudinal tubes within each of the longitudinal groove, step (c) comprises applying the flexible bio-compatible material on the mold with the plurality of longitudinal conductors and the plurality of longitudinal tubes positioned therein, step (d) comprises curing the flexible bio-compatible material so as to provide a wall band member with the plurality of longitudinal conductors and the plurality of longitudinal tubes adhered thereto;

and step (e) comprises ejecting the wall band member with the adhered plurality of longitudinal conductors and plurality of longitudinal tubes.

3. The method of claim 2, wherein the plurality of longitudinal tubes are made of silicone.

4. The method of claim 2, wherein each of a plurality of rods are positioned in each longitudinal tube before step (b).

5. The method of claim 2, wherein after curing, the plurality of longitudinal tubes comprise ridge tubes for providing ridges along the length of the wall band member.

6. The method of claim 5, wherein each longitudinal groove having the conductor positioned therein provide the electrodes at substantially the same level as the top of the ridges.

7. The method of claim 5, wherein after ejecting, a ground wire is inserted through each of the ridges via a respective proximal and distal end of each ridge.

8. The method of claim 7, wherein after inserting the ground wire, the ridges are sealed at their respective proximal and distal ends.

9. The method of claim 7, further comprising connecting a connector to the longitudinal conductor and the ground wire to provide further interface.

10. The method of claim 2, wherein after curing, each longitudinal tube comprises one of a plurality of closing element tubes to provide a closing element positioned at each of two lateral sides of the wall band member.

11. The method of claim 10, wherein portions of each of the plurality of closing elements are removed to provide two sets of closing elements, each set situated at one of the two lateral sides of the wall band member, wherein the set of closing elements situated at one lateral side form a mutually engaging interdigitating pattern with the set of closing elements situated at an opposite lateral side when the nerve cuff is in a closed position.

12. The method of claim 11, further comprising binding a sealing tube to the set of closing elements situated at the one lateral side and a ridge to the set of closing elements situated at the opposite lateral side of the wall band member.

13. The method of claim 1, wherein the longitudinal conductors protrude beyond the longitudinal grooves when positioned therein, the method further comprising cutting the protruding ends of the conductors to a desired length.

14. The method of claim 13, further comprising applying flexible bio-compatible material on the remaining protruding ends of the conductors to cap the conductors.

15. The method of claim 1, wherein each conductor comprises a pair of insulated wires.

16. The method of claim 15, wherein before positioning the conductors in the longitudinal grooves, the wires are cut to appropriate length and etched so as to facilitate adherence to a bio-compatible material after curing thereof.

17. The method of claim 1, wherein after ejecting, the excess material of the wall band member is removed.

18. The method of claim 1, wherein the flexible bio-compatible material comprises silicone.