Capsule for use in small intestine

• US 8,430,809 B2
• Filed: 02/07/2007
• Issued: 04/30/2013
• Est. Priority Date: 08/01/2005
• Status: Active Grant

• Current Assignee: G.I. View Ltd.
• Original Assignee: G.I. View Ltd.
• Inventors: Cabiri, Oz, Goldwasser, Benad, Degtiar, Borisr
• Primary Examiner(s): KASZTEJNA, MATTHEW JOHN
• Application Number:
  US11/672,369
• Publication Number:
  US 20070244359A1
• Time in Patent Office: 2,274 Days
• Field of Search: 600114-116, 600153-159, 604/95.05, 604/95.03, 604/101.02
• US Class Current: 600/116
• CPC Class Codes: A61B 1/00082 Balloons
• CPC Class Codes: A61B 1/00156 using self propulsion
• CPC Class Codes: A61B 1/041 Capsule endoscopes for imaging

Abstract

Apparatus for use in a body lumen is provided including an introducer tube configured to be advanced into a gastrointestinal tract of a subject. A guide member is coupled to a distal end of the introducer tube and is configured to be mounted in a vicinity of a valve of the subject. The apparatus also includes a capsule removably coupled to a distal portion of the introducer tube, and configured to be decoupled from the introducer tube and propelled through a small intestine of the subject once the guide member has been mounted in the vicinity of the valve. The apparatus also includes a gas supply configured to propel the capsule distally through the small intestine by generating positive gas pressure proximal to the capsule. Other embodiments are also described.

Claims

1. Apparatus, comprising:

an introducer tube, configured to be advanced into a gastrointestinal tract of a subject;

a guide member coupled to a distal end of the introducer tube said guide member being configured to be inflated and, by inflation thereof, to be mounted within a valve of the subject and to form a pressure seal therewith;

a capsule removably coupled to a distal portion of the introducer tube, said capsule comprising an inflation device configured to form a pressure seal with a wall of the small intestine;

a gas supply configured to propel the capsule distally through the small intestine by generating positive gas pressure proximal to the capsule, such that when said capsule is decoupled from the introducer tube;

said capsule is propelled through a small intestine of the subject; and

a vent tube configured to be advanced from a site that is distal to the capsule to a site that is less distal in the capsule, and to facilitate passage of a fluid from a site distal to the capsule to a site outside the body of the subject;

the capsule being configured to be advanced distally from a pyloric valve of the subject,

and wherein the vent tube is configured to be advanced through a colon of the subject.

2. The apparatus according to claim 1, wherein the inflation device comprises an inflatable balloon, and wherein the capsule is configured to regulate a diameter of the inflatable balloon in accordance with a local diameter of the small intestine.

3. The apparatus according to claim 1, wherein the gas supply is configured to deliver positive gas pressure therefrom to a volume of the small intestine proximal to the inflation device and distal to the guide member.

4. The apparatus according to claim 1, wherein the gas supply is coupled to a proximal end of the introducer tube.

5. The apparatus according to claim 4, wherein the introducer tube is configured to deliver the positive gas pressure to the small intestine proximal to the capsule, and wherein the guide member is configured to be deflated following being mounted, and to subsequently be inflated at a site distal to where the guide member had been mounted, to an extent sufficient to form a pressure seal upon inflation at the distal site.

6. The apparatus according to claim 1, wherein the gas supply is configured to inflate the guide member.

7. The apparatus according to claim 1, wherein the introducer tube is configured to be advanced distally from a rectum of the subject, and wherein the valve includes an ileocecal valve.

8. The apparatus according to claim 7, wherein the introducer tube comprises a colonoscope.

9. The apparatus according to claim 1, wherein said capsule comprises an imaging element, configured to image the gastrointestinal tract.

10. The apparatus according to claim 9, wherein the inflation device is at least 2 cm from the imaging element.

11. The apparatus according to claim 9, wherein the inflation device is 3-5 cm from the imaging element.

12. The apparatus according to claim 9, wherein the capsule comprises a transmitter configured to transmit an image to a location outside of a body of the subject.

13. The apparatus according to claim 12, wherein the transmitter comprises a radiofrequency transmission device.

14. The apparatus according to claim 1, wherein the capsule comprises the vent tube, and wherein the vent tube is configured to facilitate passage of a fluid from a site distal to the inflation device to a site proximal to the inflation device.

15. The apparatus according to claim 1, wherein the vent tube comprises at least one valve coupled to the vent tube and configured to facilitate unidirectional passage of a fluid therethrough.

16. The apparatus according to claim 1, wherein the vent tube is configured to facilitate distal motion of the capsule through the gastrointestinal tract by reducing a pressure distal to the capsule.

17. The apparatus according to claim 1, wherein the vent tube is configured to be advanced through the colon and then through an ileocecal valve of the subject.

18. The apparatus according to claim 1, wherein the vent tube is configured to be advanced through a colonoscope.

19. The apparatus according to claim 1, wherein the capsule comprises the gas supply, and wherein the gas supply comprises a gas generator.

20. The apparatus according to claim 19, wherein the as supply comprises a gas storage container.

21. The apparatus according to claim 1, comprising an inflation device diameter regulator, which is configured to regulate a diameter of the inflation device in accordance with a local diameter of the small intestine.

22. The apparatus according to claim 21, wherein the inflation device diameter regulator comprises the gas supply.

23. The apparatus according to claim 21, wherein the inflation device diameter regulator is configured to operate independently of the gas supply.

24. Apparatus, comprising:

an introducer tube, configured to be advanced into a gastrointestinal tract of a subject;

a guide member coupled to a distal end of the introducer tube said guide member being configured to be inflated and, by inflation thereof, to be mounted within a valve of the subject and to form a pressure seal therewith;

a capsule removably coupled to a distal portion of the introducer tube, said capsule comprising an inflation device configured to form a pressure seal with a wall of the small intestine;

a gas supply configured to propel the capsule distally through the small intestine by generating positive gas pressure proximal to the capsule, such that when said capsule is decoupled from the introducer tube;

said capsule is propelled through a small intestine of the subject; and

;

a vent tube configured to be advanced from a site that is distal to the capsule to a site that is less distal to the capsule, and to facilitate passage of a fluid from a site distal to the capsule to a site outside the body of the subject;

the capsule being configured to be advanced distally from an ileocecal valve of the subject, and wherein the vent tube is configured to be advanced into a small intestine of the subject through a pyloric valve of the subject.

25. The apparatus according to claim 24, wherein the inflation device comprises an inflatable balloon, and wherein the capsule is configured to regulate a diameter of the inflatable balloon in accordance with a local diameter of the small intestine.

26. The apparatus according to claim 24, wherein the gas supply is configured to deliver positive gas pressure therefrom to a volume of the small intestine proximal to the inflation device and distal to the guide member.

27. The apparatus according to claim 24, wherein the gas supply is coupled to a proximal end of the introducer tube.

28. The apparatus according to claim 27, wherein the introducer tube is configured to deliver the positive gas pressure to the small intestine proximal to the capsule, and wherein the guide member is configured to be deflated following being mounted, and to subsequently be inflated at a site distal to where the guide member had been mounted, to an extent sufficient to form a pressure seal upon inflation at the distal site.

29. The apparatus according to claim 24, wherein the gas supply is configured to inflate the guide member.

30. The apparatus according to claim 24, wherein the introducer tube is configured to be advanced distally from a rectum of the subject, and wherein the valve includes an ileocecal valve.

31. The apparatus according to claim 30, wherein the introducer tube comprises a colonoscope.

32. The apparatus according to claim 24, wherein said capsule comprising an imaging element, configured to image the gastrointestinal tract.

33. The apparatus according to claim 32, wherein the inflation device is at least 2 cm from the imaging element.

34. The apparatus according to claim 32, wherein the inflation device is 3-5 cm from the imaging element.

35. The apparatus according to claim 32, wherein the capsule comprises a transmitter configured to transmit an image to a location outside of a body of the subject.

36. The apparatus according to claim 35, wherein the transmitter comprises a radiofrequency transmission device.

37. The apparatus according to claim 24, wherein the capsule comprises the vent tube, and wherein the vent tube is configured to facilitate passage of a fluid from a site distal to the inflation device to a site proximal to the inflation device.

38. The apparatus according to claim 24, wherein the vent tube comprises at least one valve coupled to the vent tube and configured to facilitate unidirectional passage of a fluid therethrough.

39. The apparatus according to claim 24, wherein the vent tube is configured to facilitate distal motion of the capsule through the gastrointestinal tract by reducing a pressure distal to the capsule.

40. The apparatus according to claim 24, wherein the vent tube comprises a nasogastric tube.

41. The apparatus according to claim 24, wherein the vent tube is configured to be advanced through a gastroscope.

42. The apparatus according to claim 24, wherein the capsule comprises the gas supply, and wherein the gas supply comprises a gas generator.

43. The apparatus according to claim 42, wherein the gas supply comprises a gas storage container.

44. The apparatus according to claim 24, comprising an inflation device diameter regulator, which is configured to regulate a diameter of the inflation device in accordance with a local diameter of the small intestine.

45. The apparatus according to claim 44, wherein the inflation device diameter regulator comprises the gas supply.

46. The apparatus according to claim 44, wherein the inflation device diameter regulator is configured to operate independently of the gas supply.