Device, system, and method for controllably reducing inflammatory mediators in a subject
First Claim
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1. An extracorporeal device comprising:
- a treatment chamber including at least one flow route configured to receive and return peripheral blood of a subject;
at least one sensor configured to detect one or more inflammatory mediators in the peripheral blood of the subject;
at least one reservoir containing one or more reactive biological or chemical compounds that alter a functional structure of the one or more inflammatory mediators; and
a controller in communication with the at least one sensor and the at least one reservoir and configured to modulate release of the one or more reactive biological or chemical compounds from the at least one reservoir and into the peripheral blood to substantially attain a target value of the detected one or more inflammatory mediators in the peripheral blood of the subject.
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Abstract
Devices, systems, and methods are provided for controlling an inflammatory response in a subject. Extracorporeal devices, systems, and methods are provided that alter the functional structure of one or more inflammatory mediators in the peripheral blood of the subject. The device or system is useful in a method for treating an inflammatory disease or condition in the subject.
97 Citations
38 Claims
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1. An extracorporeal device comprising:
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a treatment chamber including at least one flow route configured to receive and return peripheral blood of a subject; at least one sensor configured to detect one or more inflammatory mediators in the peripheral blood of the subject; at least one reservoir containing one or more reactive biological or chemical compounds that alter a functional structure of the one or more inflammatory mediators; and a controller in communication with the at least one sensor and the at least one reservoir and configured to modulate release of the one or more reactive biological or chemical compounds from the at least one reservoir and into the peripheral blood to substantially attain a target value of the detected one or more inflammatory mediators in the peripheral blood of the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. A system comprising:
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an extracorporeal device including a treatment chamber configured to receive peripheral blood of a subject through a flow route, the treatment chamber including one or more reactive biological or chemical compounds that alter a functional structure of one or more inflammatory mediators in the peripheral blood of the subject; and at least one sensor configured to detect the one or more inflammatory mediators in the peripheral blood and configured to provide an output related thereto; and a controller configured to receive the output of the at least one sensor and configured to control interaction between the one or more biological or chemical compounds and the one or more inflammatory mediators in the treatment chamber by modulating release of the one or more reactive biological or chemical compounds into the treatment chamber; wherein the at least one sensor and the controller function relative to a target value of at least one of the one or more inflammatory mediators in the peripheral blood. - View Dependent Claims (33, 34, 35, 36, 37)
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38. An extracorporeal device comprising:
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a treatment chamber configured to receive peripheral blood of a subject through a flow route; at least one sensor configured to detect one or more inflammatory mediators in the peripheral blood of the subject; at least one reservoir containing one or more modulators that alter a functional structure of the one or more inflammatory mediators; and a controller in communication with the at least one sensor and the at least one reservoir and configured to adjust release of the one or more modulators from the at least one reservoir and into the peripheral blood to substantially attain a target value of the detected one or more inflammatory mediators in the peripheral blood of the subject.
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Specification