Method for automatically and rapidly distinguishing between control and sample solutions in a biosensor strip
First Claim
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1. A method of measuring one or more analytes in a fluid, comprising:
- introducing a biological fluid sample or control solution into an electrochemical biosensor having a working electrode and two or more electrodes selected from the group consisting of a reference electrode, counter electrode, trigger electrode and dummy electrode;
applying a first voltage across the working electrode and a first electrode selected from the group consisting of a reference electrode, counter electrode, trigger electrode and dummy electrode and obtaining a first measurement;
applying a second voltage across the first electrode and a second electrode selected from the group consisting of a reference electrode, counter electrode, trigger electrode and dummy electrode and obtaining a second measurement;
wherein the first measurement measures an analyte-dependent signal and the second measurement measures a control solution-dependent signal; and
obtaining a reading of the fluid conductivity; and
calculating the current to determine whether the fluid is a biological fluid sample or a control solution.
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Abstract
The present invention is directed to electrochemical sensors and systems and methods for electrochemically sensing a particular constituent within a fluid through the use of a diagnostic test. The methods provide for automatic discrimination of sample from control or standard solutions. A device and system used to determine a constituent level within a fluid that employ such automatic sample discrimination methods or specially formulated solutions is also provided.
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Citations
27 Claims
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1. A method of measuring one or more analytes in a fluid, comprising:
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introducing a biological fluid sample or control solution into an electrochemical biosensor having a working electrode and two or more electrodes selected from the group consisting of a reference electrode, counter electrode, trigger electrode and dummy electrode; applying a first voltage across the working electrode and a first electrode selected from the group consisting of a reference electrode, counter electrode, trigger electrode and dummy electrode and obtaining a first measurement; applying a second voltage across the first electrode and a second electrode selected from the group consisting of a reference electrode, counter electrode, trigger electrode and dummy electrode and obtaining a second measurement; wherein the first measurement measures an analyte-dependent signal and the second measurement measures a control solution-dependent signal; and obtaining a reading of the fluid conductivity; and calculating the current to determine whether the fluid is a biological fluid sample or a control solution. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method for automatically discriminating a sample solution from control solution, comprising:
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introducing a sample or control solution into an electrochemical biosensor, said biosensor comprising two or more electrodes selected from the group consisting of a reference electrode, counter electrode, trigger electrode and dummy electrode or traces, at least one working electrode, and at least one enzyme reagent; applying a first voltage between the working electrode and any one of the two or more electrodes selected from the group consisting of a reference electrode, counter electrode, trigger electrode and dummy electrode; measuring a first current resulting from the first applied voltage; applying a second voltage between two of the electrodes selected from the group consisting of a reference electrode, counter electrode, trigger electrode and dummy electrode; measuring a second current resulting from the second applied voltage; and automatically identifying the sample or control solutions based on the current values. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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Specification