Differentiation of human mesenchymal stem cells to cardiac progenitor cells that promote cardiac repair
First Claim
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1. A method for treating a subject afflicted with a cardiac disorder associated with a loss of cardiac myocytes, in vivo, comprising:
- (i) inducing differentiation of human mesenchymal stem cells, in vitro, into cardiogenic cells by forming an embryoid body of the mesenchymal stem cells;
(ii) expanding the cardiogenic cells of step (i) in culture in culture medium comprising serum without additional cardiac myocyte differentiation factors,(iii) administering a therapeutically effective amount of the cardiogenic cells of step (i) to the subject, thereby treating the cardiac disorder in the subject.
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Abstract
A method for treating a subject afflicted with a cardiac disorder, in vivo, comprises (i) inducing differentiation of a progenitor cell, in vitro, to a cardiogenic cell; and (ii) administering a therapeutically effective amount of the cardiogenic cell of step (i) to the subject, thereby treating the cardiac disorder in the subject. This invention further provides related articles of manufacture and methods.
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10 Claims
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1. A method for treating a subject afflicted with a cardiac disorder associated with a loss of cardiac myocytes, in vivo, comprising:
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(i) inducing differentiation of human mesenchymal stem cells, in vitro, into cardiogenic cells by forming an embryoid body of the mesenchymal stem cells; (ii) expanding the cardiogenic cells of step (i) in culture in culture medium comprising serum without additional cardiac myocyte differentiation factors, (iii) administering a therapeutically effective amount of the cardiogenic cells of step (i) to the subject, thereby treating the cardiac disorder in the subject. - View Dependent Claims (2, 3, 4, 5, 6)
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- 7. A method for inducing differentiation of human mesenchymal stem cells, in vitro, to cardiogenic cells comprising forming an embryoid body of the mesenchymal stem cells thereby inducing the mesenchymal stem cells to differentiate into cardiogenic cells.
- 9. Cardiogenic cells made by forming an embryoid body in vitro of mesenchymal stem cells thereby inducing the mesenchymal stem cells to differentiate into cardiogenic cells.
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