Apparatus and method for modulating neurochemical levels in the brain

• US 8,433,415 B2
• Filed: 04/18/2012
• Issued: 04/30/2013
• Est. Priority Date: 10/05/2004
• Status: Active Grant

• Current Assignee: The Trustees of Dartmounth College (Dartmouth College)
• Original Assignee: The Trustees of Dartmounth College (Dartmouth College)
• Inventors: Leiter, James C., Chemov, Mykyta M., Roberts, David W.
• Primary Examiner(s): Holmes, Rex R
• Application Number:
  US13/449,559
• Publication Number:
  US 20120209347A1
• Time in Patent Office: 377 Days
• Field of Search: 600/544, 600/545, 607/45, 607/48
• US Class Current: 607/45
• CPC Class Codes: A61B 5/4094 Diagnosing or monitoring seizure diseases, e.g. epilepsy
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease

Abstract

A treatment for Parkinson'"'"'s Disease uses a stimulus electrode implanted in a subthalamic nucleus with a chemosensor implanted in a globus pallidus pars interna (GPi) of the subject. A level of a neurochemical is sensed with the chemosensor, and compared to a desired level. When the level of the neurochemical is less than desired, an electrical stimulation is provided to the stimulus electrode. In alternative embodiments, the neurochemical sensed is glutamate or dopamine. An alternative system uses a chemosensor implanted in the striatum instead of the GPi. An alternative system for treating benign essential tremor uses a stimulus electrode implanted in the thalamus with feedback taken from a chemosensor in the striatum.

Claims

1. A deep brain stimulator device comprising:

an implantable chemosensor selected from the group consisting of a dopamine-sensitive chemosensor and a glutamate sensitive chemosensor;

an implantable stimulus electrode for electrical stimulation to a brain;

a programmable feedback controller coupled to the chemosensor and the implantable stimulus electrode;

wherein the feedback controller reads the chemosensor and provides a sequence of high frequency electrical stimulation (HFS) pulses through the stimulus electrode such that a greater number of HFS pulses are provided when levels of a neurochemical measured with the chemosensor are less than a programmed level than a number of HFS pulses provided when levels of the neurochemical measured with the chemosensor are greater than the programmed level;

wherein the chemosensor and the stimulus electrode are adapted for implantation in separate neurological structures of the brain;

wherein the HFS comprises electrical pulses at a rate of between one hundred and one hundred eighty pulses per second and of width between ten and twenty-five microseconds; and

wherein the HFS pulses have a selected pulse parameter selected from the group consisting of voltage or current, and wherein an amplitude of the selected pulse parameter is inversely proportional to the neurochemical level as measured by the chemosensor.

2. The deep brain stimulator device of claim 1, wherein the HFS pulses are provided in bursts, and the bursts are burst-length-modulated in response to chemosensor readings of levels of the neurochemical.

3. The deep brain stimulator device of claim 1, wherein the feedback controller is programmable through signals electromagnetically coupled through skin to determine a pulse parameter for use when the chemosensor indicates the neurochemical level is low and the pulse parameter for use when the chemosensor indicates the neurochemical level is high;

and wherein HFS pulses are provided in bursts, and the bursts are burst-length-modulated in response to chemosensor readings such that fewer pulses are provided when the chemosensor indicates that the neurochemical level is high.

4. The deep brain stimulator device of claim 1, wherein the feedback controller is configurable to provide HFS pulses through a determined first pair of electrodes in a multiple-electrode assembly when the neurochemical level is low and a determined second pair of electrodes when the neurochemical level is high.

5. The deep brain stimulator device of claim 4, wherein the feedback controller is programmable through signals electromagnetically coupled through skin to determine which of the first and second pairs of electrodes is used when the neurochemical level is low.

6. The deep brain stimulator device of claim 1, wherein the feedback controller is programmable through signals electromagnetically coupled through skin to follow a diurnal rhythm.