MRI-safe high impedance lead systems

• US 8,433,421 B2
• Filed: 11/07/2011
• Issued: 04/30/2013
• Est. Priority Date: 10/21/2005
• Status: Active Grant

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation), MRI Interventions, Inc. (Clearpoint Neuro, Inc.)
• Original Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation), MRI Interventions, Inc. (Clearpoint Neuro, Inc.)
• Inventors: Atalar, Ergin, Allen, Justin, Bottomley, Paul, Eldelstein, William, Karmarkar, Parag V.
• Primary Examiner(s): MANUEL, GEORGE C
• Application Number:
  US13/290,822
• Publication Number:
  US 20120071953A1
• Time in Patent Office: 540 Days
• Field of Search: 607/63
• US Class Current: 607/63
• CPC Class Codes: A61N 1/056 Transvascular endocardial electrode systems
• CPC Class Codes: A61N 1/06 for high-frequency therapy
• CPC Class Codes: A61N 1/086 Magnetic resonance imaging [MRI] compatible leads

Abstract

Some embodiments are directed to MRI/RF compatible medical interventional devices. A plurality of spaced apart high impedance circuit segments are configured to have a high impedance at a high range of radiofrequencies and a low impedance at a low range of frequencies. The high impedance circuit segments may comprise co-wound coiled inductors and can reduce, block or inhibit RJ-transmission along the lead system (20) during exposure to RF associated with a high-Held magnet MRI systems, while permuting passage of low frequency physiologic signals, treatments and/or stimuli. The devices can include at least one electrode.

Claims

1. An MRI/RF compatible medical lead, comprising:

an elongate flexible body;

a plurality of conductors extending along the elongate flexible body, each of the conductors comprising a plurality of axially spaced apart coiled segments and a plurality of linear segments with the linear segments disposed between adjacent coiled segments;

at least two electrodes disposed on a distal portion of the elongate flexible body, each electrode coupled to a different one of the plurality of conductors;

wherein the lead defines a plurality of high impedance RF traps spaced apart along a length of the elongate flexible body, each high impedance RF trap comprising at least one coiled segment of each of two or more of the plurality of conductors, wherein each high impedance RF trap is configured and arranged to inhibit flow of induced RF current at a first frequency, wherein the first frequency is at least 1 MHz, and each high impedance RF trap is configured and arranged to allow stimulation signals having a frequency of 1 kHz or less to pass through the high impedance RF trap.

2. The lead of claim 1, further comprising a plurality of spaced apart capacitors disposed between the plurality of conductors.

3. The lead of claim 2, wherein the at least two electrodes comprise at least three axially spaced apart electrodes and the plurality of conductors comprises a first conductor, a second conductor, and a third conductor, and wherein some of the plurality of capacitors are arranged to extend between the first and second conductors and others of the plurality of capacitors are arranged to extend between the second and third conductors.

4. The lead of claim 3, wherein the capacitors between the first and second conductors are axially offset from the capacitors between the second and third conductors.

5. The lead of claim 2, wherein the spaced apart capacitors are substantially regularly spaced apart axially.

6. The lead of claim 1, the elongate flexible body comprises an electrically insulating biocompatible coating.

7. The lead of claim 1, wherein first frequency is in a range from 1 to 150 MHz.

8. The lead of claim 1, wherein each high impedance RF trap is configured and arrange to allow stimulation signals having a frequency of 50 kHz or less to pass through the high impedance RF trap.

9. The lead of claim 1, further comprising

a dielectric disposed over at least one of the coiled segments;

and

a conductive shield disposed over the dielectric.

10. The lead of claim 9, farther comprising a capacitor electrically connecting at least one of the coiled segments to the conductive shield to define an RF short and low frequency open circuit.

11. A medical device, comprising:

an implantable pulse generator; and

the MRI/RF compatible medical lead of claim 1.

12. An MRI/RF compatible medical lead, comprising:

an elongate flexible body;

a first electrode disposed near an end of the flexible body;

a second electrode disposed near the end of the flexible body;

a first axially extending conductor extending along the flexible body and coupled to the first electrode;

a second axially extending conductor extending along the flexible body and coupled to the second electrode; and

a plurality of spaced apart capacitors;

wherein, at each of a plurality of intermediate locations along at least a major portion of a length of the lead, at least one of the capacitors is disposed between the first and second axially extending conductors to define a plurality of high impedance circuit segments, each high impedance circuit segment comprising at least a portion of the first axially extending conductor, at least a portion of the second axially extending conductor, and at least one of the plurality of spaced apart capacitors, wherein each of the plurality of high impedance circuit segments is configured as an RF trap that inhibits flow of induced RF current at a target range of high frequencies to inhibit heating tissue adjacent to the first and second electrodes, wherein high frequencies are frequencies at or above 1 MHz, whereby the lead has a high impedance at the target range of high frequencies and a low impedance at low frequencies.

13. The lead of claim 12, further comprising

a third electrode disposed near the end of the flexible body;

and

a third axially extending conductor extending along the flexible body and coupled to third electrode;

wherein a plurality of the capacitors are disposed between the second and third conductors.

14. The lead of claim 13, wherein the capacitors between the first and second conductors are axially offset from the capacitors between the second and third conductors.

15. The lead of claim 12, wherein at least one of the first and second conductors defines an inductor that is in electrical communication with at least two of the capacitors.

16. The lead of claim 12, wherein the spaced apart capacitors are substantially regularly spaced apart axially.

17. The lead of claim 12, wherein at least some of the spaced apart capacitors are axially spaced apart at irregular intervals.

18. The lead of claim 12, wherein the lead is formed entirely from non-magnetic materials.

19. A medical device, comprising:

an implantable pulse generator; and

the MRI/RF compatible medical lead of claim 12.

20. A system, comprising:

an implantable pulse generator comprising a housing;

a high impedance decoupling circuit disposed in the housing; and

a controller disposed in the housing; and

at least one implantable lead coupleable to the implantable pulse generator and to the decoupling circuit, the lead comprising at least one electrode disposed thereon;

wherein the controller is configured to selectively activate the decoupling circuit to provide, when the lead is coupled to the implantable pulse generator, a high impedance to the lead at high radio frequencies and a low impedance at low radio frequencies, wherein the controller is remotely controllable to activate the decoupling circuit to provide the high impedance.