Nitric oxide reactor and distributor apparatus and method

• US 8,434,475 B2
• Filed: 01/28/2009
• Issued: 05/07/2013
• Est. Priority Date: 01/31/2008
• Status: Active Grant

• Current Assignee: SYK Technologies, LLC
• Original Assignee: GeNOsys, Inc.
• Inventors: Miller, Randy J., Jones, Christie M.
• Primary Examiner(s): Anderson, Lynne
• Assistant Examiner(s): PHILIPS, BRADLEY H
• Application Number:
  US12/361,151
• Publication Number:
  US 20100018526A1
• Time in Patent Office: 1,560 Days
• Field of Search: 424/718, 128/202.26, 128/203.12, 128/203.25
• US Class Current: 128/203.12
• CPC Class Codes: A61M 16/06 Respiratory or anaesthetic masks
• CPC Class Codes: A61M 16/0666 Nasal cannulas or tubing devices for improving normal breathing through the nose A61F5/08; nose filters A62B23/06; outside holding devices A61M25/02
• CPC Class Codes: A61M 16/0672 Nasal cannula assemblies for oxygen therapy
• CPC Class Codes: A61M 16/0688 by means of an adhesive
• CPC Class Codes: A61M 16/10 Preparation of respiratory gases or vapours
• CPC Class Codes: A61M 2202/0007 introduced into the body
• CPC Class Codes: A61M 2202/0275 Nitric oxide [NO]
• CPC Class Codes: A61M 2209/06 Packaging for specific medical equipment
• CPC Class Codes: B01D 2257/404 Nitrogen oxides other than dinitrogen oxide
• CPC Class Codes: B01D 53/22 by diffusion manufacturing semi-permeable membranes B01D67/00; form, structure or properties of semi-permeable membranes B01D69/00; material for semi-permeable membranes B01D71/00
• CPC Class Codes: C01B 21/24 Nitric oxide (NO) C01B21/203 takes precedence

Abstract

A reaction and distribution system may include a distributor securable near or in a path correspond to a breathing passage such as the nostrils or the mouth of a user for delivering nitric oxide therapy thereto. The distributor may contain an internal reactor for creating the nitric oxide from reactants. Alternative embodiments may rely on a line delivering nitric oxide to the distributor from a remote generator such as a cannister carried in a pocket or placed/at the bedside of a user.

Claims

1. A method for nitric oxide therapy comprising:

providing a distributor placed to deliver nitric oxide to a breathing stream of a user;

providing a reactor producing nitric oxide wherein the reactor is portable with the user and sized to contain reactants sufficient to provide a single therapy session dose of nitric oxide and is connected in fluid communication with the distributor, wherein the reactor contains at least two reactants comprising a first reactant contained in a first chamber and a second reactant contained in a second chamber, the reactants being separated by a chamber wall that is ruptured to promote mixing;

initiating production of nitric oxide by mixing reactants in the reactor;

separating the nitric oxide from reactants and other species resulting from the reaction by filtering the nitric oxide through a porous molecular sieve that contacts one of the first or second reactants; and

delivering the nitric oxide to the distributor.

2. The method of claim 1, further comprising providing a securement to secure the distributor on the person of the user after providing the reactor.

3. The method of claim 2, wherein the distributor is positioned and secured to deliver the nitric oxide directly into the nostrils of the user.

4. The method of claim 2, wherein the securement includes an adhesive strip securing the distributor to the user.

5. The method of claim 1, wherein the concentration of nitric oxide delivered from the distributor to the user is from about one thousand parts per million to about ten thousand parts per million of nitric oxide.

6. The method of claim 1, wherein at least a portion of the second chamber is contained within the first chamber.

7. The method of claim 1, wherein the reactor is non-toxic after use.

8. The method of claim 1, wherein the first reactant is a composition of nitrogen and the second reactant is a moderate acid.

9. The method of claim 8, wherein the first reactant comprises at least one composition of nitrogen selected from the group consisting of potassium nitrite and sodium nitrite and the second reactant comprises at least two moderate acids selected from the group consisting of citric acid, ascorbic acid, and acetic acid.

10. A method for nitric oxide therapy comprising:

providing a distributor placed to deliver nitric oxide directly into the nostrils of a user;

providing a reactor comprising at least a first chamber and a second chamber wherein the first chamber contains at least one composition of nitrogen selected from the group consisting of potassium nitrite and sodium nitrite and the second chamber contains at least two moderate acids selected from the group consisting of citric acid, ascorbic acid, and acetic acid and the first and second chambers separated by a rupturable chamber wall;

the providing the reactor further comprising providing the reactor sized to be portable and connected in fluid communication with the distributor;

the providing a reactor further comprising providing a single therapy session dose of nitric oxide to the user;

initiating production of nitric oxide by mixing the reactants in the first and second chambers;

separating the nitric oxide from the reactants and other species resulting from the reaction by filtering the nitric oxide through a porous molecular sieve that contacts one of the first or second reactants; and

delivering through the distributor to the user a concentration of nitric oxide from about one thousand parts per million to about ten thousand parts per million of nitric oxide.