Materials for facilitating administration of dimethyl sulfoxide (DMSO) and related compounds

• US 8,435,224 B2
• Filed: 09/11/2006
• Issued: 05/07/2013
• Est. Priority Date: 09/12/2005
• Status: Active Grant

• Current Assignee: Abela Pharmaceuticals, Inc.
• Original Assignee: Abela Pharmaceuticals, Inc.
• Inventors: Claussen, Harvey L., Cozean, Colette, De La Torre, Jack
• Primary Examiner(s): Deak, Leslie R.
• Assistant Examiner(s): MARCETICH, ADAM M
• Application Number:
  US12/066,480
• Publication Number:
  US 20080228161A1
• Time in Patent Office: 2,430 Days
• Field of Search: 604/48, 604/93.01, 604/404, 604/408, 604/410, 604/416, 206/828, 220/500, 383/38, 383/109, 428/34.1, 137/15.11, 436/3
• US Class Current: 604/404
• CPC Class Codes: A61J 1/00 Containers specially adapted for medical or pharmaceutical purposes capsules or the like for oral use A61J3/07; specially adapted for surgical or diagnostic appliances or instruments A61B50/30; containers for radioactive substances G21F5/00
• CPC Class Codes: A61J 1/18 Arrangements for indicating condition of container contents, e.g. sterile condition
• CPC Class Codes: A61M 5/14 Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
• CPC Class Codes: B32B 27/18 characterised by the use of special additives
• CPC Class Codes: B32B 27/20 using fillers, pigments, thixotroping agents
• CPC Class Codes: B65D 55/026 initial opening or unauthorised access being indicated by a visual change using indicators other than tearable means, e.g. change of colour, pattern or opacity B65D55/066 takes precedence
• CPC Class Codes: B65D 79/02 Arrangements or devices for indicating incorrect storage or transport B65D79/005 takes precedence ; measuring devices G01
• CPC Class Codes: G01M 3/04 by detecting the presence of fluid at the leakage point
• CPC Class Codes: G01M 3/042 by using materials which expand, contract, disintegrate, or decompose in contact with a fluid G01M3/12 takes precedence

Abstract

The invention relates generally to materials for facilitating the administration of dimethyl sulfoxide (DMSO) and related compounds. In one embodiment, the invention comprises a kit comprising items used for the safe and effective administration of DMSO. In another embodiment, the invention relates to indicating containers for holding or delivering DMSO.

Claims

1. A device for facilitating administration of dimethyl sulfoxide (DMSO), comprising:

a container for holding or delivering dimethyl sulfoxide (DMSO), wherein said container comprises an inner layer, an outer layer, an indicator layer, and an intermediate layer;

wherein said inner layer comprises a material that is insoluble in dimethyl sulfoxide (DMSO);

wherein said inner layer comprises a homophase copolymer of propylene containing from about 1% to about 50% of polyethylene;

wherein said indicator layer is disposed between the inner layer and the intermediate layer;

wherein said indicator layer is configured to indicate that dimethyl sulfoxide (DMSO) has escaped from the inner layer,

wherein said intermediate layer comprises a binding layer for binding said inner layer and said outer layer; and

wherein said outer layer is resistant to abrasion.

2. The device of claim 1, wherein the indicator layer comprises a compound that changes color upon exposure to dimethyl sulfoxide (DMSO), and is thereby adapted to signal escape of dimethyl sulfoxide (DMSO) from the inner layer of said container.

3. The device of claim 1, wherein the indicator layer comprises a compound that changes light transmission upon exposure to dimethyl sulfoxide (DMSO), and is thereby adapted to signal escape of dimethyl sulfoxide (DMSO) from the inner layer of said container.

4. The device of claim 1, wherein the container comprises an IV bag, tubing, a syringe, or a catheter.

5. The device of claim 1, wherein the intermediate layer comprises a polyamide film that bonds said inner layer and said outer layer.

6. The device of claim 1, wherein the intermediate layer comprises a 9 through 13-aminoundecanoic acid polyamide.

7. The device of claim 1, wherein the intermediate layer comprises a polyolefin.

8. The device of claim 1, wherein the outer layer comprises a thermoplastic polymer.

9. A device of claim 1, wherein said device is prepared by co-extrusion.

10. A kit comprising:

a. Instructions for use;

b. At least one dimethyl sulfoxide (DMSO) resistant Stainless Steel IV needle;

c. At least one dimethyl sulfoxide (DMSO) resistant IV Catheter;

d. At least one dimethyl sulfoxide (DMSO) resistant syringe;

e. DMSO; and

f. the device of claim 1.

11. The kit of claim 10, wherein said kit further comprises adsorbant material for adsorbing the noxious odors associated with dimethyl sulfoxide (DMSO) metabolism.

12. The kit of claim 11, wherein said adsorbant material is selected from the group consisting of one or more of the following:

caps, gowns, scrubs, and linens.

13. A method for facilitating the administration of dimethyl sulfoxide (DMSO) or related compounds to a recipient, comprising:

providing a device according to claim 1; and

providing dimethyl sulfoxide (DMSO) or a related compound.