Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure
First Claim
Patent Images
1. An instrument for synthesis of radiolabeled compounds comprising:
- one or more “
hot”
component units;
at least one “
cold”
component unit;
wherein the one or more “
hot”
component units and the at least one “
cold”
component unit are separate units that are operatively connected to each other, and the one or more “
hot”
component units and the at least one “
cold”
component unit being positioned from each other to reduce radiation exposure to a user and sensitive equipment; and
one or more cassette apparatus operatively coupled to the instrument, the one or more cassette apparatus adapted to provide at least a portion of contents of the one or more cassette apparatus to either one or more of the one or more hot component units or one or more of the at least one cold component units, the one or more “
hot”
component units comprising no single-use consumables.
1 Assignment
0 Petitions
Accused Products
Abstract
Macro- and microfluidic devices and related technologies, and chemical processes using such devices. More specifically, the devices may be used for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in an efficient, compact and safe to the operator manner. In particular, embodiments of the present invention relate to an automated, multi-run, microfluidic instrument for the multi-step synthesis of radiopharmaceuticals, such as PET probes, comprising a remote shielded mini-cell containing radiation-handing components.
-
Citations
19 Claims
-
1. An instrument for synthesis of radiolabeled compounds comprising:
-
one or more “
hot”
component units;at least one “
cold”
component unit;
wherein the one or more “
hot”
component units and the at least one “
cold”
component unit are separate units that are operatively connected to each other, and the one or more “
hot”
component units and the at least one “
cold”
component unit being positioned from each other to reduce radiation exposure to a user and sensitive equipment; andone or more cassette apparatus operatively coupled to the instrument, the one or more cassette apparatus adapted to provide at least a portion of contents of the one or more cassette apparatus to either one or more of the one or more hot component units or one or more of the at least one cold component units, the one or more “
hot”
component units comprising no single-use consumables. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
-
-
15. A cassette device comprising:
-
a body portion; at least one inlet port for receiving a fluid; at least one outlet port for providing at least a portion of the fluid; and wherein the cassette device is configured to provide the at least a portion of the fluid to either one or more “
hot”
component units or at least one “
cold”
component unit, the one or more “
hot”
component units comprising no single-use consumables, andwherein the body portion includes one or more reservoirs that are arranged so as to provide contents of the reservoirs in a predetermined sequence to the one or more “
hot”
component units or the at least one “
cold”
component unit. - View Dependent Claims (16, 17, 18, 19)
-
Specification