Customizable and renewable nanostructured interface for bioelectronic applications
First Claim
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1. A bioelectronic device comprising:
- an electrically conductive substrate;
an electron-carrying mediator chemically bound to the electrically conductive substrate;
a polyelectrolyte electrostatically bound to the electrically conductive substrate via the electron-carrying mediator; and
a chemical composite comprising a biologically active compound bound, directly or indirectly, to the polyelectrolyte via an enzyme cofactor chemically bonded to the polyelectrolyte, wherein the bioelectronics device is without a bi-functional co-factor, and wherein the biologically active compound is an enzyme.
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Abstract
A chemical composite useful for preparing a bioelectronic device includes a biologically active compound, such as an enzyme, that is bound directly or indirectly to a polyelectrolyte, which can be reversibly coupled to a chemically treated electrically conductive substrate by electrostatic forces to provide biomimetic sensors, catalyst systems, and other devices having an electrode that can be regenerated and reused. Required or desired cofactors, mediators or the like may be incorporated into the devices, typically by bonding them to the treated substrate and/or the polyelectrolyte.
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Citations
10 Claims
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1. A bioelectronic device comprising:
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an electrically conductive substrate; an electron-carrying mediator chemically bound to the electrically conductive substrate; a polyelectrolyte electrostatically bound to the electrically conductive substrate via the electron-carrying mediator; and a chemical composite comprising a biologically active compound bound, directly or indirectly, to the polyelectrolyte via an enzyme cofactor chemically bonded to the polyelectrolyte, wherein the bioelectronics device is without a bi-functional co-factor, and wherein the biologically active compound is an enzyme. - View Dependent Claims (2, 3, 4, 5)
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6. A regenerable bioelectronic device comprising:
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an electron-carrying mediator chemically bound to electrically conductive substrate; and a chemical composite comprising a biologically active compound coupled to a polyeletrolyte via an enzyme cofactor chemically bonded to the polyelectrolyte, wherein the biologically active compound is reversibly bound to the chemically modified substrate by electrostatic forces, wherein the regenerable bioelectronics device is without a bi-functional co-factor, and wherein the biologically active compound is an enzyme. - View Dependent Claims (7, 8, 9, 10)
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Specification