Functionalized diphenolics and absorbable polymers therefrom

• US 8,436,201 B2
• Filed: 09/05/2012
• Issued: 05/07/2013
• Est. Priority Date: 12/09/2005
• Status: Active Grant

• Current Assignee: Bezwada Biomedical, LLC
• Original Assignee: Bezwada Biomedical, LLC
• Inventors: Bezwada, Rao S
• Primary Examiner(s): Puttlitz, Karl J
• Application Number:
  US13/604,614
• Publication Number:
  US 20130041045A1
• Time in Patent Office: 244 Days
• Field of Search: None
• US Class Current: 560/180
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: C07K 5/06078 and aromatic or cycloaliphatic
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

The present invention relates to dephenolic compounds, an example of which is shown below, which are functionalized, and polymers formed from the same.

Polymers formed from the functionalized diphenolics are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.

Claims

1. A functionalized diphenolic compound selected from:

2. A composition, comprising:

two or more different functionalized diphenolic compounds of claim 1.

3. A solvent for a drug, comprising:

at least one functionalized diphenolic compound of claim 1.

4. A nutritional composition, comprising at least one functionalized diphenolic compound of claim 1.

5. A cosmetic composition, comprising at least one functionalized diphenolic compound of claim 1 and a cosmetic ingredient.

6. A pharmaceutical composition, comprising at least one functionalized diphenolic compound of claim 1 and a pharmaceutically acceptable excipient.

7. A polymer, comprising:

a first repeating unit, formed from a functionalized diphenolic compound of claim 1 and a second repeating unit formed from a compound selected from a dicarboxylic acid, a dialcohol, a diisocyanate, an amino-alcohol, a hydroxycarboxylic acid, and a diamine.

8. The polymer of claim 7, wherein the polymer is further polymerized with a lactone monomer.

9. The polymer of claim 7, wherein the lactone monomer is selected from glycolide, lactide, ε

-caprolactone, trimethylene carbonate, and p-dioxanone.

10. A functionalized diphenolic compound of claim 1, wherein the compound is selected from:

11. A functionalized diphenolic compound of claim 1, wherein the compound is selected from:

12. A functionalized diphenolic compound of claim 1, wherein the compound is selected from:

13. A functionalized diphenolic compound of claim 1, wherein the compound is selected from:

14. A functionalized diphenolic compound of claim 1, wherein the compound is selected from:

15. A functionalized diphenolic compound of claim 1, wherein the compound is selected from: