Extruded analyte sensors and methods of using same
First Claim
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1. An electrode structure, comprising:
- a first conductive material, a second conductive material, and a dielectric material,wherein the first conductive material, the second conductive material, and the dielectric material are coextruded to provide an electrode structure having the first conductive material and the second conductive material electrically isolated by the dielectric material,wherein the electrode structure comprises a lumen, the lumen comprising a first opening, a second opening, and a lumen wall defining an inner surface of the electrode structure,wherein each of the first conductive material, the second conductive material, and the dielectric material define a portion of the lumen wall, andwherein the first conductive material, the second conductive material, and the dielectric material extend from the inner surface to an outer surface of the electrode structure.
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Abstract
The present disclosure provides electrode structures and integrated electrode structures having one or more conductive materials coextruded with one or more dielectric materials. The disclosed electrode structures can be configured for use as analyte sensors. Also provided, are methods of making and using the electrode structures and integrated electrode structures described herein.
100 Citations
33 Claims
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1. An electrode structure, comprising:
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a first conductive material, a second conductive material, and a dielectric material, wherein the first conductive material, the second conductive material, and the dielectric material are coextruded to provide an electrode structure having the first conductive material and the second conductive material electrically isolated by the dielectric material, wherein the electrode structure comprises a lumen, the lumen comprising a first opening, a second opening, and a lumen wall defining an inner surface of the electrode structure, wherein each of the first conductive material, the second conductive material, and the dielectric material define a portion of the lumen wall, and wherein the first conductive material, the second conductive material, and the dielectric material extend from the inner surface to an outer surface of the electrode structure. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method for determining a concentration of an analyte in a fluid sample from a subject, the method comprising:
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contacting the fluid sample with a sensor, the sensor comprising; an extruded electrode structure, the extruded electrode structure comprising; a first conductive material, a second conductive material, and a dielectric material, wherein the first conductive material, the second conductive material, and the dielectric material are coextruded to provide an electrode structure having the first conductive material and the second conductive material electrically isolated by the dielectric material, wherein the electrode structure comprises a lumen, the lumen comprising a first opening, a second opening, and a lumen wall defining an inner surface of the electrode structure, wherein each of the first conductive material, the second conductive material, and the dielectric material define a portion of the lumen wall, wherein the first conductive material, the second conductive material, and the dielectric material extend from the inner surface to an outer surface of the electrode structure, and wherein the first conductive material comprises a working electrode and the second conductive material comprises a reference/counter electrode, the working electrode comprising an analyte responsive enzyme disposed on, in or proximate thereto; generating a sensor signal at the working electrode; and determining the concentration of the analyte using the sensor signal. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
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Specification