Adjusted index of refraction of ocular replacement material

• US 8,439,974 B2
• Filed: 05/03/2007
• Issued: 05/14/2013
• Est. Priority Date: 05/03/2006
• Status: Expired due to Fees

• Current Assignee: Vision CRC Ltd.
• Original Assignee: Vision CRC Ltd.
• Inventors: Ho, Arthur, Holden, Brien Anthony, Manns, Fabrice, Parel, Jean-Marie Arthur
• Primary Examiner(s): McDermott, Corrine M
• Assistant Examiner(s): SHAY, RANDY CITRIN
• Application Number:
  US12/299,239
• Publication Number:
  US 20090076602A1
• Time in Patent Office: 2,203 Days
• Field of Search: 623/6.56
• US Class Current: 623/6.56
• CPC Class Codes: A61F 2/16 Intraocular lenses
• CPC Class Codes: A61F 2/1624 having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
• CPC Class Codes: A61F 2240/002 Designing or making customized prostheses
• CPC Class Codes: A61L 2430/16 for reconstruction of eye parts, e.g. intraocular lens, cornea
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: C08L 83/04 Polysiloxanes

Abstract

The present invention relates to a method of determining the IOL refractive index for an ocular replacement material for replacing tissue in the capsular bag comprising combining a neutral (non-correcting) reference refractive index (“NRRI”) of between 1.421 and 1.450 with a refractive index correction factor (“RICF”) ascertained by reference to the refractive power required to correct the patient'"'"'s refractive error. The present invention also relates to methods of treating presbyopia, myopia and hyperopia using the above method.

Claims

1. A method of treating myopia, hyperopia, or presbyopia of a subject by replacing tissue in the subject'"'"'s capsular bag comprising the steps of:

(a) determining a refractive index correction factor based on an estimate of the refractive power correction required, derived by measurement and/or examination of the subject'"'"'s eye;

(b) determining the sum of (i) the refractive index correction factor of step (a) and (ii) a neutral reference refractive index of between 1.426 and 1.442;

(c) obtaining an ocular replacement material having a refractive index of the sum of (i) and (ii) determined in step (b); and

(d) replacing the tissue in the subject'"'"'s capsular bag with the ocular replacement material.

2. A method according to claim 1 wherein the neutral reference refractive index is between 1.426 and 1.438.

3. A method according to claim 1 wherein the neutral reference refractive index is 1.427.

4. A method according to claim 1 in which the ocular replacement material is a polymer cured in situ from a cross-linkable siloxane macromonomer.

5. A method according to claim 1, wherein the ocular replacement material is curable in situ.

6. A method according to claim 1, wherein the ocular replacement material is shaped by the subject'"'"'s capsular bag.

7. A method of producing an ocular replacement material for a subject having ametropia or presbyopia, comprising selecting an ocular replacement material having a refractive index determined by summing (i) a refractive index correction factor based on an estimate of the refractive power correction required, derived by measurement and/or examination of the subject'"'"'s eye and (ii) a neutral reference refractive index of between 1.426 and 1.442.

8. A method according to claim 7 wherein the neutral reference refractive index is between 1.426 and 1.438.

9. A method according to claim 7 wherein the neutral reference refractive index is 1.427.

10. A method according to claim 7 in which the ocular replacement material is a polymer cured in situ from a cross-linkable siloxane macromonomer.

11. A method according to claim 7, wherein the ocular replacement material is curable in situ.

12. A method according to claim 7, wherein the ocular replacement material is shaped by the subject'"'"'s capsular bag.

13. A method of treating myopia, hyperopia, or presbyopia of a subject by replacing tissue in the subject'"'"'s capsular bag, comprising replacing the tissue in the subject'"'"'s capsular bag with an ocular replacement material having a refractive index determined by summing (a) a neutral reference refractive index of between 1.426 and 1.442 and (b) a refractive index correction factor ascertained by reference to refractive power required to correct the patient'"'"'s refractive error.

14. A method according to claim 13 wherein the neutral reference refractive index is between 1.426 and 1.438.

15. A method according to claim 13 wherein the neutral reference refractive index is 1.427.

16. A method according to claim 13 in which the ocular replacement material is a polymer cured in situ from a cross-linkable siloxane macromonomer.

17. A method according to claim 13, wherein the ocular replacement material is curable in situ.

18. A method according to claim 13, wherein the ocular replacement material is shaped by the subject'"'"'s capsular bag.