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Constitutively activated human G protein coupled receptors

  • US 8,440,391 B2
  • Filed: 11/26/2003
  • Issued: 05/14/2013
  • Est. Priority Date: 10/13/1998
  • Status: Expired due to Fees
First Claim
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1. A method of screening for a compound that increases cAMP levels in peripheral blood leukocytes, comprising:

  • (a) contacting a candidate compound with a G protein-coupled receptor (GPCR) that is present on the surface of a recombinant host cell or isolated membrane thereof, wherein said GPCR comprises an amino acid sequence that is at least 80% identical to the amino acid sequence of SEQ ID NO;

    82; and

    (b) determining that said candidate compound is an agonist of said GPCR; and

    (c) determining if said agonist increases cAMP levels in a peripheral blood leukocyte.

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