Pasting edge heater
First Claim
Patent Images
1. An apparatus for thermal cycling samples, the apparatus comprising:
- a sample retaining element comprising a first surface for receiving a sample containment structure, a second surface opposing the first surface, and a substantially flat edge surface,wherein the first surface provides a plurality of sample wells, andwherein the substantially flat edge surface is a third surface located between the first surface and the second surface, andwherein the sample containment structure provides containment for a plurality of samples; and
an edge heater coupled to the substantially flat edge surface of the sample retaining element,said edge heater adapted to reduce the temperature non-uniformity (TNU) of the sample retaining element;
wherein the TNU of the sample retaining element is between about 0.25°
C. to about 0.50°
C. within between about 5 seconds to about 10 seconds of achieving a sample retaining element temperature of about 95°
C.
0 Assignments
0 Petitions
Accused Products
Abstract
An apparatus and method for thermal cycling including a pasting edge heater. The pasting edge heater can provide substantial temperature uniformity throughout the retaining elements during thermal cycling by a thermoelectric module.
-
Citations
20 Claims
-
1. An apparatus for thermal cycling samples, the apparatus comprising:
-
a sample retaining element comprising a first surface for receiving a sample containment structure, a second surface opposing the first surface, and a substantially flat edge surface, wherein the first surface provides a plurality of sample wells, and wherein the substantially flat edge surface is a third surface located between the first surface and the second surface, and wherein the sample containment structure provides containment for a plurality of samples; and an edge heater coupled to the substantially flat edge surface of the sample retaining element, said edge heater adapted to reduce the temperature non-uniformity (TNU) of the sample retaining element; wherein the TNU of the sample retaining element is between about 0.25°
C. to about 0.50°
C. within between about 5 seconds to about 10 seconds of achieving a sample retaining element temperature of about 95°
C. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
-
-
11. An apparatus for thermal cycling samples, the apparatus comprising:
-
a sample retaining element comprising a first surface for receiving a sample containment structure, a second surface opposing the first surface, and a substantially flat edge surface, wherein the first surface provides a plurality of sample wells, and wherein the substantially flat edge surface is a third surface located between the first surface and the second surface, and wherein the sample retaining element provides a thermal mass for heating and cooling during thermal cycling; and an edge heater coupled to the substantially flat edge surface of the sample retaining element, said edge heater adapted to reduce the temperature nonuniformity (TNU) of the sample retaining element; wherein the TNU of the sample retaining element is about 0.25°
C. within between about 10 seconds to about 20 seconds of achieving a sample retaining element temperature of about 95°
C. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19)
-
-
20. An apparatus for thermal cycling samples, the apparatus comprising:
-
a sample retaining element comprising a first surface for receiving a sample containment structure, a second surface opposing the first surface, and a substantially flat surface, wherein the first surface provides a plurality of sample wells, and wherein the second surface is in thermal contact with at least one thermal electric module, and wherein the substantially flat surface is a third surface located between the first surface and the second surface, and wherein the sample retaining element provides a thermal mass for heating and cooling during thermal cycling; and a heater coupled to the substantially flat surface of the sample retaining element, and said heater adapted to reduce the temperature nonuniformity (TNU) of the sample retaining element.
-
Specification