Orthovoltage radiosurgery
First Claim
1. A method of treating an eye with radiotherapy, comprising:
- applying an ocular stabilizing device to the eye that limits or prevents eye movement during a selected treatment interval;
emitting a first x-ray beam, having a maximal energy of less than about 500 keV, toward a target in an eye from a first x-ray source located at a first position relative to the target, the first x-ray source having an anode with a non-zero size, the first position being within about 50 cm of the target and spaced away from the eye;
the first x-ray beam being configured such that a first beamspot at the target in the eye resulting from the first x-ray beam emission has a cross-sectional dimension that is no more than about 10% greater than a cross-sectional dimension of a second, theoretical beamspot at the target;
the second, theoretical beamspot resulting from a second, theoretical x-ray beam, having the same maximal energy as the first x-ray beam, emitted from a second, theoretical x-ray source, at the first position, having an idealized point-source anode; and
moving the eye, using the ocular stabilizing device, relative to the first x-ray beam.
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Accused Products
Abstract
A radiosurgery system is described that delivers a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, ocular structures are placed in a global coordinate system, based on ocular imaging, which leads to direction of an automated positioning system. In some embodiments, the position of an ocular structure is tracked and related to a radiosurgery system. In some embodiments, a treatment plan is utilized for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial aids in positioning the system. In some embodiments, a reflection off the eye is used to aid in positioning. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.
272 Citations
20 Claims
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1. A method of treating an eye with radiotherapy, comprising:
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applying an ocular stabilizing device to the eye that limits or prevents eye movement during a selected treatment interval; emitting a first x-ray beam, having a maximal energy of less than about 500 keV, toward a target in an eye from a first x-ray source located at a first position relative to the target, the first x-ray source having an anode with a non-zero size, the first position being within about 50 cm of the target and spaced away from the eye; the first x-ray beam being configured such that a first beamspot at the target in the eye resulting from the first x-ray beam emission has a cross-sectional dimension that is no more than about 10% greater than a cross-sectional dimension of a second, theoretical beamspot at the target; the second, theoretical beamspot resulting from a second, theoretical x-ray beam, having the same maximal energy as the first x-ray beam, emitted from a second, theoretical x-ray source, at the first position, having an idealized point-source anode; and moving the eye, using the ocular stabilizing device, relative to the first x-ray beam. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method of treating an eye with radiotherapy, comprising:
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applying an ocular stabilizing device to the eye that limits or prevents eye movement during a selected treatment interval; emitting, from a first x-ray source toward a target region in an eye, a first collimated x-ray beam having a beam axis, so as to administer a radiation dose to a target area of the target region, the first x-ray source having a maximal energy of less than about 500 keV, an anode with a non-zero size, the x-ray source being located at a first position relative to the target region during the emitting, the first position being within about 50 cm of the target and spaced away from the eye, and the first beam having; (a) a beam cross-section that is perpendicular to the beam axis, the cross-section having a centroid and a dimension defining a radial direction outward from the centroid; (b) a maximal dose region about the centroid having a maximum dose intensity; and (c) an outer dose drop-off region having a decreasing dose intensity distribution outward in the radial direction and extending to a delimiting dimension defined by a dose intensity of 20% of the maximum dose intensity; moving the eye, using the ocular stabilizing device, relative to the first collimated x-ray beam; wherein the first beam is further configured so that a first beamspot at the target area in the eye resulting from the emitting the first beam has a delimiting dimension that is no more than about 10% greater than a delimiting dimension of a second, theoretical beamspot at the target area, which second, theoretical beamspot would result from a second, theoretical collimated x-ray beam, having the same maximum dose intensity as the first beam, emitted from a second, theoretical x-ray source, at the first position, having an idealized point-source anode and the same maximal energy as the first x-ray source. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification