Stiffness enhanced filaments

• US 8,442,614 B2
• Filed: 06/21/2010
• Issued: 05/14/2013
• Est. Priority Date: 06/21/2010
• Status: Active Grant

• Current Assignee: Alfred E. Mann Foundation For Scientific Research
• Original Assignee: Alfred E. Mann Foundation For Scientific Research
• Inventors: Schulman, Joseph H.
• Primary Examiner(s): Dvorak, Linda
• Assistant Examiner(s): ANTISKAY, BRIAN MICHAEL
• Application Number:
  US12/819,698
• Publication Number:
  US 20110313271A1
• Time in Patent Office: 1,058 Days
• Field of Search: 600372-373, 600377-378, 600544-545, 607115-118
• US Class Current: 600/378
• CPC Class Codes: A61B 2562/0215 Silver or silver chloride containing
• CPC Class Codes: A61B 2562/046 in a matrix array
• CPC Class Codes: A61B 2562/125 characterised by the manufacture of electrodes
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/6868 Brain
• CPC Class Codes: A61B 5/6877 Nerve
• CPC Class Codes: A61B 5/6882 Anchoring means
• CPC Class Codes: A61L 2300/40 characterised by a specific therapeutic activity or mode of action
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/41 Anti-inflammatory agents, e.g. NSAIDs
• CPC Class Codes: A61L 2300/43 Hormones, e.g. dexamethasone
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 31/022 Metals or alloys
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61N 1/0526 Head electrodes A61N1/0551 takes precedence
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0539 Anchoring of brain electrode systems, e.g. within burr hole
• CPC Class Codes: A61N 1/0551 : Spinal or peripheral nerve electrodes
• CPC Class Codes: H05K 5/0217 : Mechanical details of casings covers, lids, hoods or members for covering apertures H05K5/03
• CPC Class Codes: H05K 5/0247 : Electrical details of casings, e.g. terminals, passages for cables or wiring

Abstract

An embodiment of the invention includes a biocompatible stiffness enhanced pliable electrically conductive filament configured for contact with living tissue and electrical communication with such tissue. The pliability of the filament allows the distal end of the filament to remain at the original site of penetration into the tissue despite the movement of the tissue relative to its surrounding environment. To temporarily stiffen the filament, a soluble stiffness enhancing coating is disposed over the filament. The coating may be in the form of a liquid which dries to a solid state after being applied to the filament and renders the filament sufficiently rigid such that under appropriate force, the filament is capable of penetrating into dense tissue. Once in place the stiffness enhancing coating dissolves due to contact with body fluids, the filament, in the absence of such coating, returns to its initial pliability. An electrical insulating layer is disposed over a portion of the filament to render it non-conductive with tissue in the area adjacent the insulating layer. For a filament with such insulating layer, the stiffness enhancing coating would be disposed over the insulating layer. The filament may also include anchoring means configured to further anchor the filament in place.

Claims

1. An implantable dual state biocompatible electrically conductive electrode comprising a single wire filament configured for contact with living tissue, said filament, having an uncoated first state wherein the filament is pliable, said filament having a coated second state wherein the filament is stiff, said filament comprising a dissolvable filament stiffness enhancing coating formed on a surface of the filament, the coating providing enhanced filament stiffness to accommodate penetration of the filament into selected living tissue such that upon dissolution of the coating, the filament returns to its uncoated state of pliability, said electrode including means for anchoring a distal end of the electrode to living tissue selected from the group consisting of at least one tine, at least one fish hook barb, at least one eyelet, and at least one rounded orifice.

2. The electrode of claim 1 wherein said filament has a distal end and a proximal end and a length defined by the longitudinal distance between the distal end and the proximal end, the filament having means capable of extension and contraction to accommodate movement of the distal end relative to the proximal end.

3. The electrode of claim 2 wherein the means capable of extension and contraction comprises a loop in the filament.

4. The electrode of claim 2 wherein the means capable of extension and contraction comprises the filament wound in the form of a spiral along at least a portion of its length.

5. The electrode of claim 2 wherein the means capable of extension and contraction comprises the filament folded in an accordion shape.

6. The electrode of claim 1 wherein the filament has a lateral dimension of between about 5 microns and 25 microns.

7. The electrode of claim 1 wherein the filament comprises a metal wire selected from the group consisting of platinum, gold, silver, iridium, stainless steel and alloys thereof.

8. The electrode of claim 1 wherein the stiffness enhancing coating is selected from the group consisting of polysaccharides, polyesters, polyvinyl alcohol, chitin, chitosan and alginates.

9. The electrode of claim 1 wherein the uncoated filament includes a layer of electrically insulating material disposed along the surface of said filament, at least a portion of the filament being devoid of said electrically insulating material so as to provide thereby a region of electrical conduction between the filament and the living tissue.

10. The electrode of claim 9 wherein the filament has a distal end and a proximal end and wherein the at least a portion of the filament being devoid of said electrically insulating material is positioned at a location between the distal end and the proximal end.

11. The electrode of claim 1 wherein the filament has a distal end and a proximal end and wherein the dissolvable filament stiffness enhancing coating is shaped into a sharp tip at the distal end of the filament to facilitate penetration of the filament into the living tissue.

12. The electrode of claim 1 wherein the stiffness enhancing coating includes an anti-inflammatory agent.

13. The electrode of claim 1 wherein the stiffness enhancing coating includes an anti-fibrotic agent.

14. The electrode of claim 1 wherein the stiffness enhancing coating includes a neural growth hormone.

15. The electrode of claim 1 wherein the stiffness enhancing coating includes an anti-infection agent.

16. The electrode of claim 2 wherein the means capable of extension and retraction comprises at least one “

S”

shaped loop capable of extension and retraction as the proximal end moves away from and towards the distal end respectively.

17. The electrode of claim 16 wherein the at least one “

S”

shaped loop comprises a plurality of “

S”

shaped loops disposed between the proximal and distal ends.

18. An implantable dual state biocompatible electrically conductive electrode comprising a filament configured for contact with living tissue, said filament, having an uncoated first state wherein the filament is pliable, said filament having a coated second state wherein the filament is stiff, said filament comprising a dissolvable filament stiffness enhancing coating formed on a surface of the filament, the coating providing enhanced filament stiffness to accommodate penetration of the filament into selected living tissue such that upon dissolution of the coating, the filament returns to its uncoated state of pliability, said filament having a distal end and a proximal end, wherein the distal end includes at least one eyelet for anchoring the distal end in selected living tissue.

19. The electrode of claim 18 wherein said filament is formed of an essentially flat foil.

20. The electrode of claim 19 wherein said foil has a thickness of about 10 microns and a width of about 25 microns.

21. The electrode of claim 18 further comprising a feedthrough assembly configured to receive and anchor the proximal end of the filament thereto.

22. The electrode of claim 21 wherein the proximal end includes an attachment extension and the feedthrough assembly includes a cavity bounded by crimp lugs, said attachment extension dimensioned to be received in said cavity and locked in place when said crimp lugs are crimped against said attachment extension.