System and method for determining the origin of a sensed beat

• US 8,442,631 B2
• Filed: 05/08/2007
• Issued: 05/14/2013
• Est. Priority Date: 05/08/2007
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: KenKnight, Bruce, Girouard, Steven D.
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): GHAND, JENNIFER LEIGH-STEWAR
• Application Number:
  US11/745,667
• Publication Number:
  US 20080281369A1
• Time in Patent Office: 2,198 Days
• Field of Search: 600509-510, 607 2- 3, 607/9
• US Class Current: 607/9
• CPC Class Codes: A61B 5/283 Invasive
• CPC Class Codes: A61B 5/29 for permanent or long-term implantation
• CPC Class Codes: A61B 5/35 by template matching
• CPC Class Codes: A61B 5/352 Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives
• CPC Class Codes: A61N 1/3702 Physiological parameters A61N1/365 takes precedence; evoked response A61N1/371

Abstract

A method for monitoring a biological cardiac pacemaker. The method may include stimulating a heart at a region selected for implantation of a biological pacemaker and sensing at least one electrical signal indicative of a cardiac depolarization originating in the region selected for implantation of the biological pacemaker. The method may further include sensing at least one subsequent electrical signal produced by the heart and determining if the subsequent electrical signal originated in the region selected for the biological pacemaker or another region of the heart.

Claims

1. An implantable medical device for monitoring an implantable biological cardiac pacemaker implanted in a heart, the device comprising:

a first sensing system for detecting a first cardiac signal at a first location in the heart wherein the first cardiac signal is a near-field signal;

a second sensing system for detecting a second cardiac signal at a second location in the heart wherein the second cardiac signal is a far-field signal; and

a processor unit configured to compare information derived from the first cardiac signal and the second cardiac signal with at least one template cardiac signal indicative of a specific location of the implantable biological pacemaker within a heart and to determine if a cardiac depolarization from one location originated in a location of the implantable biological cardiac pacemaker or in a second location near the implantable biological cardiac pacemaker based on the information derived from the first cardiac signal and the second cardiac signal, the second location selected from the group consisting of a pacing lead site, a native pacemaker site, and an ectopic site.

2. The device of claim 1, further including at least one pacing lead configured to provide cardiac stimulating pulses for pacing the heart.

3. The device of claim 2, wherein the device is configured to provide cardiac pacing with a predetermined lower rate limit and to periodically decrease the lower rate limit to evaluate pacing by the implantable biological cardiac pacemaker.

4. The device of claim 3, wherein the decrease in the lower rate limit occurs at predetermined intervals.

5. The device of claim 3, wherein the decrease in the lower rate limit is initiated by a patient or physician.

6. The device of claim 1, further including at least one defibrillation circuit configured to provide cardiac defibrillation or cardioverting shocks.

7. The device of claim 1, further including at least one pacing lead and pacing circuit configured to provide cardiac resynchronization therapy.

8. The device of claim 1, further comprising:

a template generator circuit coupled to at least one of the first sensing system and the second sensing system, wherein the template generator circuit determines a first normal sinus rhythm (NSR) representative complex and a second NSR representative complex from a plurality of cardiac complexes sensed during normal sinus rhythm;

a morphology analyzer circuit coupled to the first sensing system, where the morphology analyzer circuit locates a predetermined feature in a cardiac complex detected in the first cardiac signal and in the first NSR representative complex, wherein the predetermined feature includes a repeatedly identifiable complex section common to the cardiac complex detected in the first cardiac signal and the first NSR representative complex; and

a signal feature comparison circuit coupled to the morphology analyzer circuit and the template generator circuit, wherein the signal feature comparison circuit aligns the predetermined feature in the cardiac complex monitored in the first cardiac signal with the predetermined feature in the first NSR representative complex and compares the cardiac complex monitored in the second cardiac signal to the second NSR representative complex to determine whether the cardiac complex originated in a ventricular biological pacemaker complex.

9. The device of claim 1, further comprising:

a morphology analyzer circuit coupled to at least one of the first sensing system and the second sensing system, wherein the morphology analyzer circuit locates a position of at least one predetermined feature in a morphology of a cardiac complex in the first cardiac signal and the second cardiac signal and generates two or more scalar values as a function of the position of the at least one predetermined feature for each of the first cardiac signal and the second cardiac signal;

a template generator circuit coupled to the morphology analyzer circuit, wherein the template generator circuit creates a cardiac complex vector from the two or more scalar values generated by the morphology analyzer circuit; and

a signal feature comparison circuit coupled to the morphology analyzer circuit and the template generator circuit, wherein the signal feature comparison circuit compares the cardiac complex vector to one or more classification vectors to determine if the a sensed cardiac complex originated in a ventricular biological pacemaker complex.

10. The device of claim 1, wherein the at least one template cardiac signal is produced by stimulating the location of the implantable biological cardiac pacemaker.

11. The device of claim 10, further comprising a stimulator lead for stimulating the location of the implantable biological cardiac pacemaker.

12. The device of claim 1, wherein the second sensing system includes an electrode positioned in a housing of the implantable device.

13. The device of claim 1, wherein the second sensing system includes at least one sense amplifier configured to pass an amplified signal to a morphology analyzer circuit.

14. The device of claim 1, wherein the far-field signal is a morphology signal.

15. The device of claim 1, wherein the first sensing system includes a first channel and an electrode configured to detect the near-field signal, and wherein the second sensing system include a second channel and an electrode configured to detect the far-field signal.