Reconstituting infusion device

• US 8,444,597 B2
• Filed: 06/27/2011
• Issued: 05/21/2013
• Est. Priority Date: 09/10/2004
• Status: Active Grant

• Current Assignee: Becton, Dickinson & Co
• Original Assignee: Becton, Dickinson & Co
• Inventors: Sullivan, Vincent J., Jiang, Ge, Ferriter, Matthew S., Powell, Kenneth G., Kinsey, P. Spencer, Sahi, Carl R., Polidoro, John M.
• Primary Examiner(s): SCHMIDT, EMILY LOUISE
• Application Number:
  US13/170,149
• Publication Number:
  US 20110319814A1
• Time in Patent Office: 694 Days
• Field of Search: 604/82, 604 86- 88, 604/134, 604/131
• US Class Current: 604/82
• CPC Class Codes: A61M 2005/14256 with means for preventing access to the needle after use
• CPC Class Codes: A61M 5/1407 Infusion of two or more substances
• CPC Class Codes: A61M 5/1409 in series, e.g. first substance passing through container holding second substance, e.g. reconstitution systems needle sets A61M5/162
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61M 5/145 using pressurised reservoirs, e.g. pressurised by means of pistons
• CPC Class Codes: A61M 5/14566 with a replaceable reservoir for receiving a piston rod of the pump
• CPC Class Codes: A61M 5/14586 pressurised by means of a flexible diaphragm

Abstract

A system and method for a patch-like, self-contained multi-component substance infusion device which provides one or more substantially hidden patient needles which can be placed in fluid communication with a fluid reservoir assembly that includes a rigid bladder portion used in conjunction with a non-distensible bladder film, such as a metallized film. The device can be attached to a skin surface via an adhesive contact and a pressurization system provides a pressure to the contents of a fluid reservoir assembly. Improvements to dry powdered formulations for reconstitution for preferred use in the device are also disclosed.

Claims

1. A patch-like infusion device, comprising:

a first reservoir having at least one movable wall containing a first substance at a first pressure;

at least one patient needle in selective fluid communication with said first reservoir;

a second reservoir having at least one movable wall containing a second substance at a second pressure wherein said first and second pressures form a differential pressure;

a selective fluid communication conduit between said first reservoir and said second reservoir, wherein when said selective fluid communication conduit between said first reservoir and said second reservoir is enabled, said first substance and said second substance are intermingled to form a medicament, and whereby said intermingling is caused by said differential pressure;

a spring having a central aperture for applying pressure to said movable wall of said first reservoir to cause fluid to flow from said first reservoir to said patient needle;

a pin engageable with said central aperture and disengageable therefrom for causing said spring to begin applying a third pressure to said first reservoir when said infusion device is placed into operation; and

an activation means wherein said movable wall of said second reservoir is moved by said activation means, thereby reducing a volume of said second reservoir whereby said volume reduction results in movement of said medicament from said second chamber into said first chamber.

2. A patch-like infusion device as claimed in claim 1, wherein disengagement of said pin from said aperture occurs automatically when the user performs another operation on said infusion device.

3. A patch-like infusion device as claimed in claim 2, wherein said operation comprises operating a pushbutton.

4. A patch-like infusion device as claimed in claim 2, wherein said operation comprises removing a pushbutton guard or interlock.

5. A patch-like infusion device as claimed in claim 2, wherein said spring is a disk spring.

6. A patch-like infusion device as claimed in claim 1, further comprising an adhesive disposed on a surface of the patch-like infusion device for attaching the patch-like infusion device to a patient'"'"'s skin.