Molecular separators, concentrators, and detectors preparatory to sensor operation, and methods of minimizing false positives in sensor operations
First Claim
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1. An interactive interrogator system for detecting a target substance, comprising:
- a concentration cell;
a first sensor tuned to detect the target substance in a range of 1 ppm to 1 ppt, but that may provide a false alarm for an interferent, wherein the first sensor comprises at least one nanotube and the first sensor is situated in the concentration cell;
a second sensor which is an ambiguity resolver and which is dependent on a different physical parameter than the first sensor, wherein the second sensor is in a separate cell outside where the first sensor is located;
a computerized interrogator that is interactive with a human user, wherein when the first sensor has returned a positive indication for presence of a target substance, the interrogator performs steps comprising;
presenting a query sequence to the human user for response,as the user makes response, receiving response data,processing the response data including screening for whether the target substance is actually present in the concentration cell and being detected by the first sensor or whether instead the first sensor is likely to be issuing a false alarm;
wherein the interrogator is connected to the ambiguity resolver;
a library in a computer-readable form of at least the target substance and possible interferents, wherein the library is contained in or receivable by the interrogator.
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Abstract
As an elegant solution for minimizing false positives returned by a sensor tuned to an analyte molecule, filters constructed of carbon nanotubes are positioned relative to the sensor to limit the sensor to being exposed to molecules within a defined range of sizes, with too-big molecules being excluded from reaching the sensor by one filter, and too-small molecules being pumped out through another, finer filter before the sensor is operated.
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Citations
7 Claims
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1. An interactive interrogator system for detecting a target substance, comprising:
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a concentration cell; a first sensor tuned to detect the target substance in a range of 1 ppm to 1 ppt, but that may provide a false alarm for an interferent, wherein the first sensor comprises at least one nanotube and the first sensor is situated in the concentration cell; a second sensor which is an ambiguity resolver and which is dependent on a different physical parameter than the first sensor, wherein the second sensor is in a separate cell outside where the first sensor is located; a computerized interrogator that is interactive with a human user, wherein when the first sensor has returned a positive indication for presence of a target substance, the interrogator performs steps comprising; presenting a query sequence to the human user for response, as the user makes response, receiving response data, processing the response data including screening for whether the target substance is actually present in the concentration cell and being detected by the first sensor or whether instead the first sensor is likely to be issuing a false alarm; wherein the interrogator is connected to the ambiguity resolver; a library in a computer-readable form of at least the target substance and possible interferents, wherein the library is contained in or receivable by the interrogator.
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2. A system into which is received an initial sample of various-sized molecules which are to be sorted by size, wherein the initial sample comprises at least one of an analyte molecule to which a first sensor is tuned and/or a molecule that upon coming in contact with the first sensor evokes a false positive for the analyte molecule;
- the system comprising;
an inlet through which the initial sample is received into the system; a container; a first valve that when opened permits the initial sample to be received into an upstream section of the container; a first screen which is an entry screen that is encountered by the initial sample and that comprises an array of nanotubes of an inner diameter that excludes molecules based on size from entering the container, a second screen, downstream of the first screen and comprising an array of nanotubes of an inner diameter that permits molecules smaller than the second screen to exit the container and blocks molecules bigger than the second screen; the first sensor, disposed in the container to only be in contact with a subset of molecules of a predefined size range bounded by a size range defined by the first screen and the second screen; a pump downstream of the second screen; a second valve that when opened, and when the pump is operated, permit too-small molecules to exit the container; a second sensor which is an ambiguity resolver and which is dependent on a different physical parameter than the first sensor, wherein the second sensor is in a separate cell outside where the first sensor is located. - View Dependent Claims (3, 4, 5, 6, 7)
- the system comprising;
Specification