Method and system for performing biopsies

• US 8,447,384 B2
• Filed: 06/12/2009
• Issued: 05/21/2013
• Est. Priority Date: 06/20/2008
• Status: Active Grant

• Current Assignee: Koninklijke Philips N.V., The United States of America As Represented By The Secretary of Agriculture
• Original Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Inventors: Xu, Sheng, Kruecker, Jochen, Shechter, Guy, Farmer, Ian, Choyke, Peter Lyle, Pinto, Peter, Wood, Bradford J.
• Primary Examiner(s): Cattungal, Sanjay
• Application Number:
  US12/993,854
• Publication Number:
  US 20110082363A1
• Time in Patent Office: 1,439 Days
• Field of Search: 600407-429, 600437-469, 606/130
• US Class Current: 600/429
• CPC Class Codes: A61B 10/0233 Pointed or sharp biopsy instruments
• CPC Class Codes: A61B 2034/2051 Electromagnetic tracking systems
• CPC Class Codes: A61B 2090/364 Correlation of different images or relation of image positions in respect to the body
• CPC Class Codes: A61B 2090/374 NMR or MRI
• CPC Class Codes: A61B 2090/378 using ultrasound
• CPC Class Codes: A61B 34/20 Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
• CPC Class Codes: A61B 8/4254 using sensors mounted on the probe

Abstract

A method and system for performing biopsies can include an imaging system for obtaining diagnostic images of a target region; a tracking system; a probe having a deployable biopsy needle for performing a biopsy procedure where the tracking system generates tracking information for at least one of the probe and the biopsy needle; an ultrasound imaging system for obtaining ultrasound imaging of the target region; and a computer in communication with the tracking system, the imaging system and the ultrasound imaging system. The computer can register the tracking system with the imaging system. The computer transfers a marking of a biopsy site associated with the biopsy procedure from the ultrasound imaging to the diagnostic images based on the tracking information and the registration of the tracking system with the diagnostic images.

Claims

1. A method of using a tracking system for performing a biopsy, the method comprising acts of:

providing a probe with a deployable biopsy needle;

acquiring diagnostic images of a target region including a biopsy site;

registering the tracking system with the diagnostic images;

obtaining ultrasound images of the target region during the biopsy;

the tracking system acquiring tracking information for a location of at least one of the biopsy needle and the probe during the biopsy;

marking the location at the biopsy site on the ultrasound images; and

transforming the location at the biopsy site from the ultrasound images to the diagnostic images based on the tracking information and the registration of the tracking system with the diagnostic images.

2. The method of claim 1, wherein the tracking system is an electromagnetic tracking system, and at least one of the probe and the biopsy needle comprises one or more electromagnetic sensors.

3. The method of claim 1 wherein the target region is a prostate and the diagnostic images are acquired by a magnetic resonance imaging system and further comprising an act of displaying an MRI image showing the biopsy site on a computing device.

4. The method of claim 1, wherein the act of:

marking of the location at the biopsy site on the ultrasound images is performed in real-time; and

further comprising an act of using the diagnostic images having the marked location at the biopsy site thereon for performing an additional medical procedure.

5. The method of claim 1, further comprising acts of:

acquiring the locations at the biopsy sites for a plurality of patients;

associating the locations at the biopsy sites with a common coordinate system; and

generating a distribution map using the common coordinate system.

6. The method of claim 5 further comprising acts of:

training at least one clinician to perform the biopsy using the distribution map; and

using a correlation between the diagnostic images and pathological examination in an image processing algorithm for detection of cancer.

7. The method of claim 1, further comprising an act of performing imaging correction to account for motion of the target region.

8. The method of claim 1, further comprising an act of adjusting at least one of an ultrasound transducer type and a patient position during a medical procedure based on the diagnostic images having the marked location at the biopsy sites.

9. A non-transitory computer-readable storage medium for storing computer-executable code configured to cause a computing device in which the computer-readable storage medium is loaded to execute a method of using a tracking system for performing a biopsy, the method comprising acts of:

acquiring diagnostic images of a target region including a biopsy site;

registering the tracking system with the diagnostic images;

obtaining ultrasound images of the target region during the biopsy;

the tracking system acquiring tracking information for a location of at least one of the probe, the biopsy needle and the needle guide during a biopsy; and

transferring a marking of the location at the biopsy site from the ultrasound images to the diagnostic images based on the tracking information and the registration of the tracking system with the diagnostic images.

10. The computer-readable storage medium of claim 9, further comprising an act of marking the location at the biopsy site on the ultrasound images.

11. The computer-readable storage medium of claim 9 further comprising an act of detecting a position of the biopsy needle based on the ultrasound imaging and defining the marking of the location at the biopsy site based on the detected position.

12. The computer-readable storage medium of claim 9, wherein the diagnostic images are generated using at least one of magnetic resonance imaging, computed tomography, contrast ultrasound, positron emission tomography, and single photon emission computed tomography.

13. The computer-readable storage medium of claim 9 further comprising an act of generating a map distribution comprising the marked locations at the biopsy sites for a plurality of patients.

14. The computer-readable storage medium of claim 9 further comprising an act of displaying the marking of the location at the biopsy site on the diagnostic images using a shape corresponding to a biopsy sample obtained by the biopsy needle.

15. A biopsy system comprising:

an imaging system for acquiring diagnostic images of a target region including a biopsy site;

a probe having a deployable biopsy needle for performing a biopsy procedure;

a tracking system for acquiring tracking information for a location of at least one of the probe and the biopsy needle;

an ultrasound imaging system for obtaining ultrasound images of the target region; and

a computer in communication with the tracking system, the imaging system and the ultrasound imaging system, configured the tracking system with the diagnostic images acquired by the imaging system, and

configured to transfer a marking of the location at the biopsy site associated with the biopsy procedure from the ultrasound images to the diagnostic images based on the tracking information and the registration of the tracking system with the diagnostic images.

16. The system of claim 15, wherein the tracking system is an electromagnetic tracking system, and wherein at least one of the biopsy needle and the probe comprises one or more electromagnetic sensors.

17. The system of claim 16, wherein the probe is a trans-rectal ultrasound probe having a needle guide for deploying the biopsy needle, and wherein the ultrasound imaging is obtained using the TRUS probe.

18. The system of claim 15, wherein the computer retrieves the marking of the location at the biopsy site in real-time.

19. The system of claim 15, wherein the imaging system is one of a magnetic resonance imaging system, a computed tomography system, a contrast ultrasound system, a positron emission tomography system, and a single photon emission computed tomography system.

20. The system of claim 15, wherein the computer generates a map distribution comprising marked biopsy sites for a plurality of patients.