System and method for managing detrimental cardiac remodeling

• US 8,447,399 B2
• Filed: 04/01/2008
• Issued: 05/21/2013
• Est. Priority Date: 08/19/1996
• Status: Expired due to Fees

• Current Assignee: MR3 Medical, LLC
• Original Assignee: MR3 Medical, LLC
• Inventors: Mower, Morton M.
• Primary Examiner(s): GETZOW, SCOTT M
• Application Number:
  US12/060,334
• Publication Number:
  US 20080287855A1
• Time in Patent Office: 1,876 Days
• Field of Search: 607 4- 28
• US Class Current: 607/9
• CPC Class Codes: A61N 1/0587 Epicardial electrode systems; Endocardial electrodes piercing the pericardium
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation

Abstract

A system and method for managing and inhibiting cardiac remodeling in MI patients. Bi-ventricular stimulation is constantly provided with and without sensing to encourage normal pumping of the heart on a consistent basis. Pulses are administered using an anodal pulse followed by a cathodal pulse to stimulate cardiac muscle contraction. Stem cells are administered to MI areas to encourage regeneration of cardiac tissue in the damaged area. Stimulation may be provided to both healthy and compromised cardiac tissue.

Claims

1. An apparatus for minimizing cardiac remodeling of a non-arrhythmic patient comprising:

a heart stimulation device comprising control circuitry, wherein the control circuitry is configured with instructions for stimulating cardiac tissue, wherein the cardiac tissue comprises healthy and compromised areas;

a left ventricular electrode group, wherein the left ventricular electrode group comprises LV electrodes attached to the left ventricle at increasing distances from the AV node; and

a right ventricular electrode group, wherein the right ventricular electrode group comprises RV electrodes attached to the left ventricle at increasing distances from the AV node,

wherein the heart stimulation device is configured to attach to the LV and RV electrodes, and wherein instructions for stimulating cardiac tissue include instructions configured to cause the control circuitry to perform operations comprising;

generating a timing signal coincident with a refractory period; and

in response to the timing signal, sending a series of biphasic pulses to the LV and RV electrodes, wherein the series of biphasic pulses is sequenced such that an initial pulse arrives at an LV electrode and an RV electrode nearest the AV junction, and subsequent pulses arrive at an LV and an RV electrode progressively further from the AV junction.

2. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient of claim 1, wherein at least one of the biphasic pulses in the series of biphasic pulses is excitatory.

3. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient of claim 1, wherein at least one of the biphasic pulses in the series of biphasic pulses is non-excitatory.

4. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient of claim 1, wherein each one of the biphasic pulses in the series of biphasic pulses comprises:

a first stimulation phase having a first phase polarity, a first phase amplitude, a first phase shape, and a first phase duration, so as to precondition the myocardium to accept subsequent stimulation, and

a second stimulation phase having a second phase polarity, a second phase amplitude that is larger in absolute value than the first phase amplitude, a second phase shape, and a second phase duration.

5. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient according to claim 4, wherein the first phase polarity is positive, and the second phase polarity is negative.

6. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient according to claim 4, wherein the first phase amplitude is at a maximum subthreshold amplitude.

7. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient according to claim 1, wherein a compromised area of cardiac tissue has stem cells deposited thereon.

8. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient according to claim 7, wherein the LV and RV electrodes are located so as to electrically stimulate the compromised area of cardiac tissue on which stem cells have been deposited.

9. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient according to claim 7, wherein the LV and RV electrodes are located so as to preclude electrical stimulation of the compromised area of cardiac tissue on which stem cells have been deposited.

10. An apparatus for minimizing cardiac remodeling of a non-arrhythmic patient comprising:

a heart stimulation device comprising control circuitry, wherein the control circuitry is configured with instructions for stimulating cardiac tissue, wherein the cardiac tissue comprises healthy and compromised areas;

a left ventricular electrode group, wherein the left ventricular electrode group comprises LV electrodes attached to the left ventricle at increasing distances from the AV node;

a right ventricular electrode group, wherein the right ventricular electrode group comprises RV electrodes attached to the left ventricle at increasing distances from the AV node; and

a sensor configured to sense excitation of a heart chamber,

wherein the heart stimulation device is configured to attach to the LV and RV electrodes and to the sensor, and wherein the instructions for stimulating cardiac tissue include instructions configured to cause the control circuitry to perform operations comprising;

in response to a signal from the sensor, sending a series of biphasic pulses to the LV and RV electrodes, wherein the series of biphasic pulses is sequenced such that an initial pulse arrives at an LV electrode and an RV electrode nearest the AV junction and subsequent pulses arrive at an LV and an RV electrode progressively further from the AV junction.

11. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient of claim 10, wherein at least one of the biphasic pulses in the series of biphasic pulses is excitatory.

12. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient of claim 10, wherein at least one of the biphasic pulses in the series of biphasic pulses is non-excitatory.

13. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient of claim 10, wherein each of the biphasic pulses in the series of biphasic pulses comprises:

a first stimulation phase having a first phase polarity, a first phase amplitude, a first phase shape, and a first phase duration, so as to precondition the myocardium to accept subsequent stimulation, and

a second stimulation phase having a second phase polarity, a second phase amplitude that is larger in absolute value than the first phase amplitude, a second phase shape, and a second phase duration.

14. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient according to claim 13, wherein the first phase polarity is positive, and the second phase polarity is negative.

15. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient according to claim 13, wherein the first phase amplitude is at a maximum subthreshold amplitude.

16. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient according to claim 10, wherein a compromised area of cardiac tissue has stem cells deposited thereon.

17. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient according to claim 16, wherein the LV and RV electrodes are located so as to electrically stimulate the compromised area of cardiac tissue on which stem cells have been deposited.

18. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient according to claim 16, wherein the LV and RV electrodes are located so as to preclude electrical stimulation of the compromised area of cardiac tissue on which stem cells have been deposited.

19. An apparatus for minimizing cardiac remodeling of a non-arrhythmic patient comprising:

a heart stimulation device comprising control circuitry, wherein the control circuitry is configured with instructions for stimulating cardiac tissue, wherein the cardiac tissue comprises;

a healthy area; and

a compromised area that has stem cells deposited thereon;

a left ventricular electrode group, wherein the left ventricular electrode group comprises LV electrodes attached to the left ventricle at increasing distances from the AV node;

a right ventricular electrode group, wherein the right ventricular electrode group comprises RV electrodes attached to the left ventricle at increasing distances from the AV node; and

a sensor configured to sense excitation of a heart chamber,

wherein the heart stimulation device is configured to attach to the LV and RV electrodes and to the sensor, and wherein instructions for stimulating cardiac tissue include instructions configured to cause the control circuitry to perform operations comprising;

in response to a signal from the sensor, sending biphasic stimulation to the LV and RV electrodes, wherein the series of biphasic pulses is sequenced such that an initial pulse arrives at an LV electrode and an RV electrode nearest the AV junction, and subsequent pulses arrive at an LV and an RV electrode progressively further from the AV junction; and

wherein the biphasic stimulation comprises;

a first stimulation phase having a first phase polarity, a first phase amplitude, a first phase shape, and a first phase duration, so as to precondition the myocardium to accept subsequent stimulation, and

a second stimulation phase having a second phase polarity, a second phase amplitude that is larger in absolute value than the first phase amplitude, a second phase shape, and a second phase duration.

20. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient according to claim 19, wherein the LV and RV electrodes are located so as to electrically stimulate the compromised area of cardiac tissue on which stem cells have been deposited.

21. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient according to claim 19, wherein the LV and RV electrodes are located so as to preclude electrical stimulation of the compromised area of cardiac tissue on which stem cells have been deposited.