Medical method and device for monitoring a neural brain network
First Claim
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1. A method comprising:
- receiving, with a processor, a first bioelectrical signal sensed at a first location within a brain of a patient;
receiving, with the processor, a second bioelectrical signal sensed at a second location within the brain of the patient, wherein the first and second locations are spatially distinct;
determining, with the processor, a limit cycle plot of the first and second bioelectrical signals, wherein the limit cycle plot is indicative of a trajectory of the first and second bioelectrical signals;
determining, with the processor, that the brain is in a first state based on the limit cycle plot; and
controlling delivery of therapy to the patient based on determining that the brain is in the first state, wherein controlling delivery of therapy to the patient comprises selecting the therapy to produce a second state in the brain.
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Abstract
Bioelectrical signals may be sensed within the brain by two or more electrodes to determine characteristics of a function of the brain. The signals obtained by the electrodes may be plotted over time to determine whether the brain function exhibits a normal or an abnormal pattern. If the brain function exhibits an abnormal pattern, an implantable medical device may dynamically determine based on the abnormal pattern and a previously-obtained plot associated with normal brain function, an appropriate electrical stimulation therapy. Application of the appropriate electrical stimulation therapy causes the brain function to shift from the abnormal pattern to the normal pattern.
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Citations
28 Claims
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1. A method comprising:
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receiving, with a processor, a first bioelectrical signal sensed at a first location within a brain of a patient; receiving, with the processor, a second bioelectrical signal sensed at a second location within the brain of the patient, wherein the first and second locations are spatially distinct; determining, with the processor, a limit cycle plot of the first and second bioelectrical signals, wherein the limit cycle plot is indicative of a trajectory of the first and second bioelectrical signals; determining, with the processor, that the brain is in a first state based on the limit cycle plot; and controlling delivery of therapy to the patient based on determining that the brain is in the first state, wherein controlling delivery of therapy to the patient comprises selecting the therapy to produce a second state in the brain. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A system comprising:
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a sensing module configured to sense a first bioelectrical signal at a first location within a brain of a patient and a second bioelectrical signal at a second location within the brain of the patient, wherein the first and second locations are spatially distinct; and a processor configured to determine a limit cycle plot of the first and second bioelectrical signals, wherein the limit cycle plot is indicative of a trajectory of the first and second bioelectrical signals, determine that the brain is in a first state based on the limit cycle plot, and control delivery of therapy to the patient based on determining that the brain is in the first state, by at least selecting the therapy to produce a second state in the brain. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A non-transitory computer-readable medium comprising instructions that, upon execution, cause a programmable processor to:
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receive a first bioelectrical signal sensed at a first location within a brain of a patient; receive a second bioelectrical signal sensed at a second location within the brain of the patient, wherein the first and second locations are spatially distinct; determine a limit cycle plot of the first and second bioelectrical signals, wherein the limit cycle plot is indicative of a trajectory of the first and second bioelectrical signals; determine that the brain is in a first state based on the limit cycle plot; and control delivery of therapy to the patient based on determining that the brain is in the first state by at least selecting the therapy produce a second state in the brain. - View Dependent Claims (22, 23, 24)
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25. A system comprising:
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means for receiving a first bioelectrical signal sensed at a first location within a brain of a patient; means for receiving a second bioelectrical brain signal sensed at a second location within the brain of the patient, wherein the first and second locations are spatially distinct; means for determining a limit cycle plot of the first and second bioelectrical signals, wherein the limit cycle plot is indicative of a trajectory of the first and second bioelectrical signals; means for determining that the brain is in a first state based on the limit cycle plot; and means for controlling delivery of therapy to the patient based on determining that the brain is in the first state, wherein the means for controlling delivery of therapy comprises means for selecting the therapy to produce a second state in the brain. - View Dependent Claims (26, 27, 28)
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Specification