Endoprosthesis coating

• US 8,449,603 B2
• Filed: 06/17/2009
• Issued: 05/28/2013
• Est. Priority Date: 06/18/2008
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Weber, Jan, Atanasoska, Liliana, Zoromski, Michele
• Primary Examiner(s): GHERBI, SUZETTE JAIME J
• Application Number:
  US12/486,295
• Publication Number:
  US 20090319032A1
• Time in Patent Office: 1,441 Days
• Field of Search: 623 142- 148, 424/424, 427/2.1
• US Class Current: 623/1.48
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61L 31/088 Other specific inorganic materials not covered by A61L31/084 or A61L31/086
• CPC Class Codes: A61L 31/146 Porous materials, e.g. foams or sponges

Abstract

An endoprosthesis, e.g., a stent (e.g., a drug eluting stent), that includes a porous surface and hollow elements integrated with a coating on the surface and a method of making the same are disclosed.

Claims

1. An endoprosthesis, comprising:

a surface, the surface comprising a surface porous structure of a first material, the surface porous structure defining pores and being corrugated;

a coating of a second material on the surface porous structure; and

a plurality of hollow elements, at least some of the hollow elements being formed in one or more of the pores of the surface porous structure, and at least some of the hollow elements each comprising a wall formed of the second material and comprising a portion of a continuous part of the coating, the wall defining an interior space, the interior space containing a therapeutic agent.

2. The endoprosthesis of claim 1, wherein the first material comprises a metal.

3. The endoprosthesis of claim 1, wherein the second material comprises a ceramic material.

4. The endoprosthesis of claim 3, wherein the ceramic material comprises silicon oxide, titanium oxide, iridium oxide or a mixture thereof.

5. The endoprosthesis of claim 1, wherein the wall defining the interior space comprises a wall porous structure.

6. The endoprosthesis of claim 5, wherein the wall porous structure defines a plurality of pores each having a width of about 0.5 nm to about 500 nm.

7. The endoprosthesis of claim 1, wherein the pores of the surface porous structure have a width and a depth of about 1 nm to about 25 μ

m.

8. The endoprosthesis of claim 1, wherein the hollow elements are hollow spheres.

9. The endoprosthesis of claim 8, wherein the hollow spheres have an outer diameter of about 10 nm to about 5 μ

m.

10. The endoprosthesis of claim 1, wherein the coating of the second material has a thickness of about 1 nm to about 1 μ

m.

11. The endoprosthesis of claim 1, wherein the endoprosthesis has a body formed of the first material.

12. The endoprosthesis of claim 5, wherein the wall porous structure comprises interconnected pores defining passageways in communication between interior and exterior of the hollow elements.