Portable coagulation monitoring device and method of assessing coagulation response
First Claim
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1. A method of measuring coagulation response in a blood sample, comprising:
- placing a sample droplet of whole blood between and in contact with first and second facing surfaces of two oppositely disposed parallel glass plates;
moving at least one plate linearly with respect to the other plate at a predetermined speed sufficient to activate platelets through exposure to shear forces; and
optically detecting, via measurement of mechanical displacement, the interaction between the first and second surfaces resulting from changes in the viscosity of the sample fluid and binding to the plate surfaces in order to measure coagulation response of the droplet of blood.
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Abstract
A device, system and method is disclosed in which small volume blood samples are subjected to shear forces and shear stresses between two parallel planar surfaces to which linear motion trajectories are imparted. The formation of clots or coagulation of the sample is measured from dynamic mechanical coupling which occurs between the two parallel planar surfaces. Detection of the coagulation response can be achieved through optical probing or by measurement of physical effects of the blood sample binding to the planar surfaces, and restricting movement thereof.
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Citations
16 Claims
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1. A method of measuring coagulation response in a blood sample, comprising:
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placing a sample droplet of whole blood between and in contact with first and second facing surfaces of two oppositely disposed parallel glass plates; moving at least one plate linearly with respect to the other plate at a predetermined speed sufficient to activate platelets through exposure to shear forces; and optically detecting, via measurement of mechanical displacement, the interaction between the first and second surfaces resulting from changes in the viscosity of the sample fluid and binding to the plate surfaces in order to measure coagulation response of the droplet of blood. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method of measuring coagulation response in a blood sample comprising:
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placing a sample droplet of whole blood between and in contact with first and second facing surfaces of two oppositely disposed glass plates; moving at least one plate linearly with respect to the other plate at a first speed sufficient to activate platelets through exposure to shear forces; optically detecting, via measurement of mechanical displacement, the interaction between the first and second surfaces in order to measure a first coagulation response of the blood indicative of platelet response; moving at least one plate linearly with respect to the other plate at a second speed; and optically detecting, via measurement of mechanical displacement and coupling, the interaction between the movement of the first and second surfaces in order to measure the terminal coagulation response of the blood indicative of rate and completeness of fibrin polymerization. - View Dependent Claims (16)
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Specification