Glucagon analogs exhibiting enhanced solubility and stability in physiological pH buffers
First Claim
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1. A glucagon peptide with glucagon agonist activity, comprising an amino acid sequence with up to 10 amino acid modifications, relative to SEQ ID NO:
- 1, wherein the glutamine at position 3 of SEQ ID NO;
1 is substituted with a different amino acid comprising a side chain of Structure I, II, or III;
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Abstract
Modified glucagon peptides are disclosed having improved solubility and/or half-life while retaining glucagon agonist activity. The glycogen peptides have been modified by substitution of native amino acids with, and/or addition of, charged amino acids to the carboxy terminus of the peptide. The modified glucagon agonists can be further modified by pegylation, or the addition of a carboxy terminal peptide selected from the group consisting of SEQ ID NO: 20, SEQ ID NO: 21, SEQ ID NO: 23, or both to further enhance the solubility of the glucagon agonist analogs.
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16 Claims
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1. A glucagon peptide with glucagon agonist activity, comprising an amino acid sequence with up to 10 amino acid modifications, relative to SEQ ID NO:
- 1, wherein the glutamine at position 3 of SEQ ID NO;
1 is substituted with a different amino acid comprising a side chain of Structure I, II, or III;
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
- 1, wherein the glutamine at position 3 of SEQ ID NO;
Specification