Immunoregulatory peptides and methods of use
First Claim
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1. A pharmaceutical peptide composition comprising SEQ ID NO:
- 319 conjugated to a transducing sequence at the C-terminus; and
a pharmaceutically-acceptable excipient, wherein the pharmaceutical composition is in a unit dosage form.
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Abstract
Peptides for the treatment of inflammation, and therapeutic uses and methods of using the same are disclosed. Peptides including a transducing sequence are effective for inhibiting cytokine activity and TNF-α secretion through interaction with toll-like receptors. Experiments are described illustrating the efficacy of the compounds in treating otitis media.
30 Citations
33 Claims
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1. A pharmaceutical peptide composition comprising SEQ ID NO:
- 319 conjugated to a transducing sequence at the C-terminus; and
a pharmaceutically-acceptable excipient, wherein the pharmaceutical composition is in a unit dosage form. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- 319 conjugated to a transducing sequence at the C-terminus; and
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10. A synthetic peptide of SEQ ID NO:
- 319 conjugated to a transducing sequence at the C-terminus, wherein at least one amino acid residue of the synthetic peptide is in the D-configuration.
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11. A method of inhibiting cellular activity mediated by a toll-like receptor, the method comprising administering to an organism in need thereof an effective amount of a pharmaceutical peptide composition comprising SEQ ID NO:
- 319 conjugated to a transducing sequence at the C-terminus and a pharmaceutically-acceptable excipient, wherein the pharmaceutical composition is in a unit dosage form.
- View Dependent Claims (12, 13)
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14. A method of treating inflammation in an animal, the method comprising administering to an animal in need thereof a therapeutically-effective amount of a pharmaceutical peptide composition comprising SEQ ID NO:
- 319 conjugated to a transducing sequence at the C-terminus and a pharmaceutically-acceptable excipient, wherein the pharmaceutical composition is in a unit dosage form.
- View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. A method of treating hearing impairment in an animal, the method comprising administering a therapeutically-effective amount of a peptide composition comprising SEQ ID NO:
- 319 conjugated to a transducing sequence at the C-terminus to an animal having middle and/or inner ear inflammation and reduced hearing.
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27. A method of treating middle and/or inner ear inflammation, the method comprising administering a therapeutically-effective amount of a peptide composition comprising SEQ ID NO:
- 319 conjugated to a transducing sequence at the C-terminus to a tympanic membrane of an animal in need thereof.
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28. A synthetic peptide SEQ ID NO:
- 319 conjugated to a transducing sequence at the C-terminus.
- View Dependent Claims (29, 30, 31, 32, 33)
Specification