Biomedical devices containing internal wetting agents
First Claim
1. A silicone hydrogel contact lens having a water content of about 10 to about 60 weight % and an average tear film breakup time is at least about 7 seconds after about 7 days of wear, wherein said contact lens is formed from a reaction mixture comprising at least one hydrophilic monomer, high molecular weight hydrophilic polymer and a compatibilizing effective amount of hydroxyl-functionalized silicone-containing monomer selected from the group consisting of (3-methacryloxy-2-hydroxypropyloxy)propylbis(trimethylsiloxy)methylsilane, (2-methacryloxy-3-hydroxypropyloxy)propylbis(trimethylsiloxy)methylsilane, (3-methacryloxy-2-hydroxypropyloxy)propyltris(trimethylsiloxy)silane, bis-3-methacryloxy-2-hydroxypropyloxypropyl polydimethylsiloxane, 3-methacryloxy-2-(2-hydroxyethoxy)propyloxy)propylbis(trimethylsiloxy)methylsilane, N,N,N′
- ,N′
-tetrakis(3-methacryloxy-2-hydroxypropyl)-α
,ω
-bis-3-aminopropyl-polydimethylsiloxane and mixtures thereof.
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Accused Products
Abstract
This invention includes a wettable biomedical device containing a high molecular weight hydrophilic polymer and a hydroxyl-functionalized silicone-containing monomer.
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Citations
50 Claims
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1. A silicone hydrogel contact lens having a water content of about 10 to about 60 weight % and an average tear film breakup time is at least about 7 seconds after about 7 days of wear, wherein said contact lens is formed from a reaction mixture comprising at least one hydrophilic monomer, high molecular weight hydrophilic polymer and a compatibilizing effective amount of hydroxyl-functionalized silicone-containing monomer selected from the group consisting of (3-methacryloxy-2-hydroxypropyloxy)propylbis(trimethylsiloxy)methylsilane, (2-methacryloxy-3-hydroxypropyloxy)propylbis(trimethylsiloxy)methylsilane, (3-methacryloxy-2-hydroxypropyloxy)propyltris(trimethylsiloxy)silane, bis-3-methacryloxy-2-hydroxypropyloxypropyl polydimethylsiloxane, 3-methacryloxy-2-(2-hydroxyethoxy)propyloxy)propylbis(trimethylsiloxy)methylsilane, N,N,N′
- ,N′
-tetrakis(3-methacryloxy-2-hydroxypropyl)-α
,ω
-bis-3-aminopropyl-polydimethylsiloxane and mixtures thereof. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49)
- ,N′
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2. A silicone hydrogel contact lens having a water content of about 10 to about 60 weight % and an average tear film breakup time is at least about 7 seconds after about 7 days of wear, wherein said contact lens is formed from a reaction mixture comprising at least one hydrophilic monomer, high molecular weight hydrophilic polymer and a compatibilizing effective amount of hydroxyl-functionalized silicone-containing monomer comprising bis-3-methacryloxy-2-hydroxypropyloxypropyl polydimethylsiloxane.
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50. A silicone hydrogel contact lens having a water content of about 10 to about 60 weight % formed from a reaction mixture comprising at least one hydrophilic monomer, high molecular weight hydrophilic polymer and a compatibilizing effective amount of hydroxyl-functionalized silicone-containing monomer selected from the group consisting of (3-methacryloxy-2-hydroxypropyloxy)propylbis(trimethylsiloxy)methylsilane, (2-methacryloxy-3-hydroxypropyloxy)propylbis(trimethylsiloxy)methylsilane, (3-methacryloxy-2-hydroxypropyloxy)propyltris(trimethylsiloxy)silane, bis-3-methacryloxy-2-hydroxypropyloxypropyl polydimethylsiloxane, 3-methacryloxy-2-(2-hydroxyethoxy)propyloxy)propylbis(trimethylsiloxy)methylsilane, N,N,N′
- ,N′
-tetrakis(3-methacryloxy-2-hydroxypropyl)-α
,ω
-bis-3-aminopropyl-polydimethylsiloxane and mixtures thereof, and an average tear film breakup time after one week of wear, which is higher than an etafilcon lens after one week of wear.
- ,N′
Specification