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Single-chain TNFSF fusion polypeptides

  • US 8,450,460 B2
  • Filed: 07/18/2009
  • Issued: 05/28/2013
  • Est. Priority Date: 07/21/2008
  • Status: Active Grant
First Claim
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1. A single-chain fusion polypeptide comprising:

  • (i) a first soluble tumor necrosis factor (TNF) superfamily cytokine domain,(ii) a first peptide linker,(iii) a second soluble TNF superfamily cytokine domain,(iv) a second peptide linker, and(v) a third soluble TNF superfamily cytokine domain,wherein each of the soluble TNF superfamily cytokine domains lacks a stalk region and the first and the second peptide linkers independently have a length of 3-8 amino acids.

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