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Soluble hyaluronidase glycoprotein (sHASEGP), process for preparing the same, uses and pharmaceutical compositions comprising thereof

  • US 8,450,470 B2
  • Filed: 06/03/2009
  • Issued: 05/28/2013
  • Est. Priority Date: 03/05/2003
  • Status: Active Grant
First Claim
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1. A nucleic acid molecule, comprising a sequence of nucleotides encoding a hyaluronidase polypeptide, wherein:

  • the nucleic acid molecule includes a stop codon, whereby the encoded hyaluronidase polypeptide is produced upon expression; and

    the encoded hyaluronidase polypeptide is selected from among;

    a polypeptide that consists of a sequence of amino acids selected from among amino acid residues 1-477, 1-478, 1-479, 1-480, 1-481, 1-482, 1-483, 36-477, 36-478, 36-479, 36-480, 36-481, 36-482 or 36-483 of SEQ ID NO;

    1; and

    a polypeptide that consists of a sequence of amino acids that contains amino acid substitutions in the sequence of amino acids set forth as 1-477, 1-478, 1-479, 1-480, 1-481, 1-482, 1-483, 36-477, 36-478, 36-479, 36-480, 36-481, 36-482 or 36-483 of SEQ ID NO;

    1, whereby the amino acid-substituted hyaluronidase glycoprotein consists of a sequence of amino acids that has at least 95% amino acid sequence identity to a sequence of amino acids set forth as amino acid residues 1-477, 1-478, 1-479, 1-480, 1-481, 1-482, 1-483, 36-477, 36-478, 36-479, 36-480, 36-481, 36-482 or 36-483 of SEQ ID NO;

    1.

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