Stand-alone mini gamma camera including a localization system for intrasurgical use

• US 8,450,694 B2
• Filed: 12/22/2006
• Issued: 05/28/2013
• Est. Priority Date: 12/26/2005
• Status: Active Grant

• Current Assignee: Consejo Superior de Investigaciones Científicas,, General Equipment For Medical Imaging, S.A, Universidad de Navarra
• Original Assignee: Consejo Superior de Investigaciones Científicas,, Universidad de Navarra
• Inventors: Lerche, Christoph, Baviera, Jose Maria Benlloch, Martinez, Filomeno Sanchez, Hernandez, Noriel Pavon, Leiva, Jesus Modia
• Primary Examiner(s): Bryant, Casey
• Application Number:
  US12/159,307
• Publication Number:
  US 20100025587A1
• Time in Patent Office: 2,349 Days
• Field of Search: 250/361.R, 250/370.09, 250/370.11, 600/407
• US Class Current: 250/363.04
• CPC Class Codes: A61B 2034/2068 using pointers, e.g. pointers having reference marks for determining coordinates of body points
• CPC Class Codes: A61B 2090/363 Use of fiducial points
• CPC Class Codes: A61B 2090/366 using projection of images directly onto the body
• CPC Class Codes: A61B 2090/392 Radioactive markers
• CPC Class Codes: A61B 34/20 Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
• CPC Class Codes: A61B 6/037 Emission tomography
• CPC Class Codes: A61B 6/4258 for detecting non x-ray radiation, e.g. gamma radiation A61B6/037 takes precedence
• CPC Class Codes: A61B 90/36 Image-producing devices or illumination devices not otherwise provided for
• CPC Class Codes: A61B 90/361 Image-producing devices, e.g. surgical cameras
• CPC Class Codes: G01T 1/161 Applications in the field of nuclear medicine, e.g. in vivo counting apparatus for radiation diagnosis A61B6/00
• CPC Class Codes: G01T 1/1642 using a scintillation crystal and position sensing photodetector arrays, e.g. ANGER cameras

Abstract

The invention relates to a portable mini gamma camera for intrasurgical use. The inventive camera is based on scintillation crystals and comprises a stand-alone device, i.e. all of the necessary systems have been integrated next to the sensor head and no other system is required. The camera can be hot-swapped to any computer using different types of interface, such as to meet medical grade specifications. The camera can be self-powered, can save energy and enables software and firmware to be updated from the Internet and images to be formed in real time. Any gamma ray detector based on continuous scintillation crystals can be provided with a system for focusing the scintillation light emitted by the gamma ray in order to improve spatial resolution. The invention also relates to novel methods for locating radiation-emitting objects and for measuring physical variables, based on radioactive and laser emission pointers.

Claims

1. A system for the diagnosis, navigation, positioning, localization and detection of radioactive sources in radio-guided surgery, comprising:

a localization system based on radioactive pointers capable of being moved over the radioactive sources to be observed;

a laser-based light pointer system, to indicate a specific point of the image on an observation area; and

a mini gamma camera, that captures images of organs and images of at least one radioactive pointer,

wherein the localization system detects the point of impact of the radioactive pointer on a detection plane of the mini gamma camera and the estimated distance from the pointer to the impact point on the camera on the basis of the activity of the radioactive pointer and its apparent activity.

2. The system according to claim 1, further comprising a control system comprising a computer with a specific and updatable scintigraphy software and a connection media between the mini gamma camera and the control system for a specific standard interface, wherein the control system controls the mini gamma camera, sending automatic orders by means of two-directional data communication and receiving acquired data from the mini gamma camera.

3. The system according to claim 2, further comprising a radiation level detector based in a computer software update of the system.

4. The system according to claim 2, comprising a plurality of mini gamma cameras which are mechanically correlated and operated simultaneously by the control system, in order to achieve stereoscopic vision, thereby making it possible to view gamma ray emitting objects in three dimensions.

5. The system according to claim 1, wherein the mini gamma camera is integrated into a sensor head, comprising:

a casing having an interior space, the casing comprising an electromagnetic screen;

an interchangeable gamma ray collimation system, disposed within the interior space of the casing, that allows the gamma rays to pass only through holes established for the correct formation of the image;

a continuous-type scintillation crystal that transduces the energy from a gamma ray generating a large number of visible light photons, which can be detected by a photodetector;

a hot-swappable computer interface, cooperatively connected to the processing electronics, designed for low-energy consumption; and

an anti-radiation screen, covering the side, rear and front surfaces of the camera, except in the area of the collimation system;

wherein all of the above-listed elements of the mini gamma camera have been integrated together with the sensor head, forming a compact piece of stand-alone equipment without the need for any other additional electronic system.

6. The system according to claim 5, wherein the hot-swappable interface of the mini gamma camera is selected from the group consisting of USB 1.1, USB 2.0, wireless USB, IEEE 802.15, and IEEE 1394.

7. The system according to claim 5, wherein the mini gamma camera is configured to draw power from a power source selected from the group consisting of the hot-swappable computer interface, and a battery.

8. The system according to claim 5, wherein the mini gamma camera is configurable to enter into an energy-saving mode.

9. The system according to claim 5, wherein the continuous-type scintillation crystal has an inhomogeneity in a detection area of less than about 5% up to about 80% of said area.

10. The system according to claim 9, wherein the surface of the continuous type scintillation crystal of the mini gamma camera via which the gamma rays penetrate is roughly polished, painted with a dry, reflective white paint, and coated with a reflective white epoxy layer thereon.

11. The system according to claim 9, wherein the surface of the continuous-type scintillation crystal of the mini gamma camera through which the gamma rays penetrate is finely polished and coated with a self-reflective layer.

12. The system according to claim 9, wherein the surface of the continuous-type scintillation crystal of the mini gamma camera that is in contact with the photodetector is roughly polished.

13. The system according to claim 9, wherein the small side surfaces of the continuous-type scintillation crystal of the mini gamma camera are roughly polished, painted with dry, absorbent black paint and coated with an absorbent black epoxy layer.

14. The system according to claim 5, wherein the mini gamma camera further comprises a system for focusing the scintillation light emitted by the gamma ray, reducing the width of light distribution that reaches the photodetector.

15. The system according to claim 5, wherein the scintillation crystal of the mini camera comprises a chemical element belonging to the rare earth type.

16. The system according to claim 5, wherein the photodetector of the mini camera comprises a position sensitive flat panel photomultiplier.

17. The system according to claim 1, wherein the mini gamma camera is a SPECT or PET gamma camera.

18. The system according to claim 1, wherein the radioactive pointer is a transparent pointer that emits radiation that can be distinguished from the radiation that is to be observed, a bright pointer that emits radiation that cannot be distinguished from the radiation that is to be observed, or an opaque pointer that does not radiate or allow the radiation that is to be observed to pass.

19. A system for the diagnosis, navigation, positioning, localization and detection of radioactive sources in radio-guided surgery according to claim 1, further comprising a collimator and wherein the localization system determines the distance of the radioactive pointer in relation to the camera, based on the dimensions of the radioactive pointer, the dimensions of the collimator and measuring an apparent size of the image formed by the radioactive pointer.

20. A system for the diagnosis, navigation, positioning, localization and detection of radioactive sources in radio-guided surgery according to claim 1, wherein the laser-based light pointer system comprises laser emitters situated asymmetrically in relation to the axis of movement between the surface and the emitter system in such a way that the geometrical form of the light that is generated and its position does not depend on the distance between the emitter system and the illuminated surface.

21. The system according to claim 1, wherein the radioactive sources are lymph nodes, thyroid, parathyroid, kidneys, colon, breasts and other organs of a patient who has been administered a radioactive dose of a radiopharmaceutical related to the organ and a function to be observed.