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Non-invasive methods of using spectral information in determining analyte concentrations

  • US 8,452,357 B2
  • Filed: 10/08/2009
  • Issued: 05/28/2013
  • Est. Priority Date: 08/22/2006
  • Status: Active Grant
First Claim
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1. A non-invasive method of determining the concentration of an analyte using Raman spectral information, the method comprising the acts of:

  • applying a high-intensity, narrow band of light to a first side of tissue, the high-intensity light entering the tissue at a first side and generating a Raman signal;

    providing a Raman-generating material adapted to generate Raman signals;

    reflecting the high-intensity light from the Raman-generating material so as to produce an additional Raman signal that passes towards the first side of the tissue;

    reflecting the Raman signal generated from the high-intensity light entering the tissue towards the first side of the tissue via the Raman-generating material;

    collecting the Raman signal generated from the high-intensity light entering the tissue and the additional Raman signal generated from the Raman-generating material; and

    determining the analyte concentration using information from the collected Raman signals.

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